Pyocyanine
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(Redirected from Pyocyanin)
| Pyocyanine[1] | |
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5-Methylphenazin-1-one |
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Other names
Pyocyanin; Pyrocyanine; 5-Methyl-1(5H)-phenazinone; Sanasin; Sanazin |
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| Identifiers | |
| CAS number | 85-66-5  |
| PubChem | 6817 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C13H10N2O |
| Molar mass | 210.23 g mol−1 |
| Appearance | Solid |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Pyocyanine (or pyocyanin) is an antibiotic pigment produced by the Gram negative bacterium Pseudomonas aeruginosa. It is a redox-active virulence factor that allows P. aeruginosa to kill cells, disrupt cilia action, inhibit lymphocyte proliferation, and alter phagocytic function. Due to its redox-active properties, pyocyanin generates reactive oxygen species that induce oxidative stress in bacterial[2] and mammalian cells.[3]
[edit] References
- ^ Pyocyanin at Sigma-Aldrich
- ^ Hassan HM, Fridovich I (1980). "Mechanism of the antibiotic effect of pyocyanine". J Bacteriol 141 (1): 156–163. PMC 293551. PMID 6243619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=293551.
- ^ Muller M. (2002). "Pyocyanin induces oxidative stress in human endothelial cells and modulates the glutathione redox cycle". Free Radic Biol Med 33 (11): 1527–1533. doi:10.1016/S0891-5849(02)01087-0. PMID 12446210.
