Pyrantel

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Pyrantel
Pyrantel.png
Pyrantel ball-and-stick animation.gif
Names
IUPAC name
1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine
Identifiers
15686-83-6 YesY
ATC code P02CC01
QP52AF02
ChEBI CHEBI:8654 N
ChEMBL ChEMBL1626223 N
Jmol-3D images Image
KEGG D08451 YesY
MeSH Pyrantel
PubChem 708857
UNII 4QIH0N49E7 YesY
Properties
C11H14N2S
Molar mass 206.31 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Pyrantel is an antinematodal thiophene. It is often prescribed by veterinarians to treat and prevent the occurrence of intestinal parasites in small animal pets.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]

Mechanism of action[edit]

Pyrantel is a nicotinic receptor agonist.[2][3] Like levamisole and the related pyrimidine morantel, it can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle. This has been studied in body wall muscle preparation of the parasitic nematode Ascaris.[4]

See also[edit]

References[edit]

  1. ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014. 
  2. ^ Aceves, J., Erlij, D., and Martinez-Maranon, R. (1970). The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br. J. Pharmacol. 38, 602–607.
  3. ^ Aubry, M.L., Cowell, P., Davey, M.J., and Shevde, S. (1970). Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Pharmacol. 38, 332–344.
  4. ^ Martin, R.J., Verma, S., Levandoski, M., Clark, C.L., Qian, H., Stewart, M., and Robertson, A.P. (2005). Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole. Parasitology 131, S71–S84.