|Jmol-3D images||Image 1|
|Molar mass||80.09 g/mol|
|Melting point||52 °C (126 °F; 325 K)|
|Boiling point||115 °C (239 °F; 388 K)|
|Solubility in water||Soluble|
|Acidity (pKa)||0.37 (protonated pyrazine)|
|S-phrases||S16, S26, S36|
|Flash point||55 °C c.c.|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
Pyrazine is a symmetrical molecule with point group D2h. Derivatives such as phenazine are well known for their antitumor, antibiotic and diuretic activities. Pyrazine is less basic in nature than pyridine, pyridazine and pyrimidine. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human polymorphonuclear leukocytes, and is a component of some herbs in traditional Chinese medicine.
Many methods exist for the organic synthesis of pyrazine and its derivatives. Some of these are among the oldest synthesis reactions still in use.
In the Staedel–Rugheimer pyrazine synthesis (1876) 2-chloroacetophenone is reacted with ammonia to the amino ketone, then condensed and then oxidized to a pyrazine  A variation is the Gutknecht pyrazine synthesis (1879) also based on this selfcondensation, but differing in the way the alpha-ketoamine is synthesised 
- Pyrimidine, an analog with the second nitrogen atom in position 3
- Pyridazine, an analog with the second nitrogen atom in position 2
- Pyridine, an analog with only one nitrogen atom
- Benzene, an analog without the nitrogen atoms
- Simple aromatic rings
- Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.
- Zhang, Zhaohui (2003). "Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes". Life Sciences 72 (22): 2465–2472. doi:10.1016/S0024-3205(03)00139-5.
- Ueber die Einwirkung von Ammoniak auf Chloracetylbenzol (pp. 563–564) W. Staedel, L. Rügheimer doi:10.1002/cber.187600901174 Berichte der deutschen chemischen Gesellschaft Volume 9, Issue 1, pp. 563–564, 1876
- Mittheilungen Ueber Nitrosoäthylmethylketon H. Gutknecht Berichte der deutschen chemischen Gesellschaft Volume 12, Issue 2 , pp. 2290–2292, 1879 doi:10.1002/cber.187901202284
- Heterocyclic chemistry T.L. Gilchrist ISBN 0-582-01421-2
- G. Gastaldi, Gazz. Chim. Ital. 51, (1921) 233
- Amines: Synthesis, Properties and Applications Stephen A. Lawrence 2004 Cambridge University Press ISBN 0-521-78284-8