Pyridoxine 5'-phosphate synthase

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Pyridoxine 5'-phosphate synthase
Identifiers
EC number 2.6.99.2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a pyridoxine 5'-phosphate synthase (EC 2.6.99.2) is an enzyme that catalyzes the chemical reaction

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate \rightleftharpoons pyridoxine 5'-phosphate + phosphate + 2 H2O

Thus, the two substrates of this enzyme are 1-deoxy-D-xylulose 5-phosphate and 3-amino-2-oxopropyl phosphate, whereas its 3 products are pyridoxine 5'-phosphate, phosphate, and H2O.

This enzyme belongs to the family of transferases, specifically those transferring nitrogenous groups transferring other nitrogenous groups. The systematic name of this enzyme class is 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing). Other names in common use include pyridoxine 5-phosphate phospho lyase, PNP synthase, and PdxJ. This enzyme participates in vitamin B6 metabolism.

References[edit]

  • Garrido-Franco M (2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond". Biochim. Biophys. Acta. 1647 (1–2): 92–7. doi:10.1016/s1570-9639(03)00065-7. PMID 12686115. 
  • Garrido-Franco M, Laber B, Huber R, Clausen T (2002). "Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis". J. Mol. Biol. 321 (4): 601–12. doi:10.1016/S0022-2836(02)00695-2. PMID 12206776. 
  • Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS (1999). "Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein". FEBS. Lett. 449 (1): 45–8. doi:10.1016/S0014-5793(99)00393-2. PMID 10225425. 
  • Franco MG, Laber B, Huber R, Clausen T (2001). "Structural basis for the function of pyridoxine 5'-phosphate synthase". Structure. 9 (3): 245–53. doi:10.1016/S0969-2126(01)00584-6. PMID 11286891.