Pyroglutamylated RFamide peptide receptor

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Pyroglutamylated RFamide peptide receptor
Symbols QRFPR ; AQ27; GPR103; SP9155
External IDs OMIM606925 MGI2677633 HomoloGene18865 IUPHAR: 333 ChEMBL: 5852 GeneCards: QRFPR Gene
Species Human Mouse
Entrez 84109 229214
Ensembl ENSG00000186867 ENSMUSG00000058400
UniProt Q96P65 P83861
RefSeq (mRNA) NM_198179 NM_198192
RefSeq (protein) NP_937822 NP_937835
Location (UCSC) Chr 4:
122.25 – 122.3 Mb
Chr 3:
36.18 – 36.22 Mb
PubMed search [1] [2]

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.[1][2]


G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[3] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[4]


  1. ^ a b "Entrez Gene: GPR103 G protein-coupled receptor 103". 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  3. ^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592. 
  4. ^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173. 

Further reading[edit]

External links[edit]

  • "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.