Pyrroline-2-carboxylate reductase

pyrroline-2-carboxylate reductase
Identifiers
EC number	1.5.1.1
CAS number	9029-16-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a pyrroline-2-carboxylate reductase (EC 1.5.1.1) is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+ $\rightleftharpoons$ 1-pyrroline-2-carboxylate + NAD(P)H + H⁺

The 3 substrates of this enzyme are L-proline, NAD⁺, and NADP⁺, whereas its 4 products are 1-pyrroline-2-carboxylate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 2-oxidoreductase. This enzyme is also called Delta1-pyrroline-2-carboxylate reductase. This enzyme participates in lysine degradation and arginine and proline metabolism.

References

• Meister A, Radhakrishnan AN and Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229 (2): 789–800. PMID 13502341.