Pyrrolizidine alkaloids (PAs; sometimes referred to as necine bases) are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Pyrrolizidine alkaloids are produced by plants as a defense mechanism against insect herbivores. More than 660 PAs and PA N-oxides have been identified in over 6,000 plants, and about half of them exhibit hepatotoxicity. They are found frequently in plants in the Boraginaceae, Asteraceae, Orchidaceae and Fabaceae families; less frequently in the Convolvulaceae and Poaceae, and in at least one species in the Lamiaceae. It has been estimated that 3% of the world’s flowering plants contain pyrrolizidine alkaloids. Honey can contain pyrrolizidine alkaloids, as can grains, milk, offal and eggs. To date (2011), there is no international regulation of PAs in food, unlike those for herbs and medicines.
Unsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. PAs also cause hepatic veno-occlusive disease and liver cancer. PAs are tumorigenic. Disease associated with consumption of PAs is known as pyrrolizidine alkaloidosis.
Some ruminant animals, for example cattle, showed no change in liver enzyme activities or any clinical signs of poisoning when fed plants containing pyrrolizidine alkaloids. Yet Australian studies have demonstrated toxicity Sheep, goats and cattle are much more resistant and tolerate much higher PA dosages, thought to be due to thorough detoxification via PA-destroying rumen microbes. Males react more sensitively than females and fetuses and children.
PA is also used as a defense mechanism for some organisms such as Utetheisa ornatrix. Utetheisa ornatrix caterpillars obtain these toxins from their food plants and use them as a deterrent for predators. PAs protect them from most of their natural enemies. The toxins stay in these organisms even when they metamorphose into adult moths, continuing to protect them throughout their adult stage.
Many plants contain pyrrolizidine alkaloids, and in turn there are many insects which consume the plants and build up the alkaloids in their bodies. For example, male Queens utilize pyrrolizidine alkaloids to produce pheromones useful for mating.
Plants species containing pyrrolizidine alkaloids
- Adenostyles alliariae
- Adenostyles glabra
- Ageratum conyzoides
- Ageratum houstonianum
- Arnebia euchroma
- Borago officinalis(<10ppm, non-toxic)
- Cacalia hastata
- Cacalia hupehensis
- Chromolaena odorata
- Cordia myxa
- Crassocephalum crepidioides
- Crotalaria albida
- Crotalaria assamica
- Crotalaria crispat
- Crotalaria dura
- Crotalaria globifera
- Crotalaria mucronata
- Crotalaria sesseliflora
- Crotalaria spectabilis
- Crotalaria tetragona
- Crotalaria retusa
- Cynoglossum amabile
- Cynoglossum lanceolatum
- Cynoglossum officinale
- Cynoglossum zeylanicum
- Echium plantagineum
- Echium vulgare
- Emilia sonchifolia
- Eupatorium cannabinum
- Eupatorium chinense
- Eupatorium fortunei
- Eupatorium japonicum
- Eupatorium purpureum
- Farfugium japonicum
- Gynura bicolor
- Gynura divaricata
- Gynura segetum
- Heliotropium amplexicaule
- Heliotropium europaeum
- Heliotropium indicum
- Lappula intermedia
- Ligularia cymbulifera
- Ligularia dentata
- Ligularia duiformis
- Ligularia heterophylla
- Ligularia hodgsonii
- Ligularia intermedia
- Ligularia lapathifolia
- Ligularia lidjiangensis
- Ligularia platyglossa
- Ligularia tongolensis
- Ligularia tsanchanensis
- Ligularia vellerea
- Liparis nervosa
- Lithospermum erythrorizon
- Neurolaena lobata
- Petasites japonicus
- Senecio alpinus
- Senecio argunensis
- Senecio brasiliensis
- Senecio chrysanthemoides
- Senecio cineraria
- Senecio glabellus
- Senecio integrifolius var. fauriri
- Senecio interggerrimus
- Senecio jacobaea
- Senecio lautus
- Senecio linearifolius
- Senecio madagascariensis
- Senecio nemorensis
- Senecio quadridentatus
- Senecio riddelli
- Senecio scandens
- Senecio vulgaris
- Syneilesis aconitifolia
- Symphytum officinale
- Tussilago farfara
Please note - list not complete.
The effect of PAs in humans, that is PAILDs, of epidemic proportions was recorded after a long field level epidemiological investigation in the northern region of Ethiopia- Tigray.
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