QARS

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Glutaminyl-tRNA synthetase
Identifiers
Symbols QARS ; GLNRS; PRO2195
External IDs OMIM603727 MGI1915851 HomoloGene3704 ChEMBL: 3054 GeneCards: QARS Gene
EC number 6.1.1.18
RNA expression pattern
PBB GE QARS 217846 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5859 97541
Ensembl ENSG00000172053 ENSMUSG00000032604
UniProt P47897 Q8R1V9
RefSeq (mRNA) NM_001272073 NM_001168270
RefSeq (protein) NP_001259002 NP_001161742
Location (UCSC) Chr 3:
49.13 – 49.14 Mb
Chr 9:
108.51 – 108.52 Mb
PubMed search [1] [2]

Glutaminyl-tRNA synthetase is an enzyme that in humans is encoded by the QARS gene.[1][2][3]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.[3]

Interactions[edit]

QARS has been shown to interact with RARS.[4]

References[edit]

  1. ^ Lamour V, Quevillon S, Diriong S, N'Guyen VC, Lipinski M, Mirande M (October 1994). "Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer". Proc Natl Acad Sci U S A 91 (18): 8670–8674. doi:10.1073/pnas.91.18.8670. PMC 44668. PMID 8078941. 
  2. ^ Durkin ME, Jager AC, Khurana TS, Nielsen FC, Albrechtsen R, Wewer UM (July 1999). "Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS)". Cytogenet Cell Genet 84 (3–4): 173–178. doi:10.1159/000015249. PMID 10393422. 
  3. ^ a b "Entrez Gene: QARS glutaminyl-tRNA synthetase". 
  4. ^ Kim, T; Park S G, Kim J E, Seol W, Ko Y G, Kim S (July 2000). "Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex". J. Biol. Chem. (UNITED STATES) 275 (28): 21768–21772. doi:10.1074/jbc.M002404200. ISSN 0021-9258. PMID 10801842. 

Further reading[edit]