QSOX1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Quiescin Q6 sulfhydryl oxidase 1
Protein QSOX1 PDB 3LLI.png
Rendering based on PDB 3LLI.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols QSOX1 ; Q6; QSCN6
External IDs OMIM603120 MGI1330818 HomoloGene37690 GeneCards: QSOX1 Gene
EC number 1.8.3.2
RNA expression pattern
PBB GE QSCN6 201482 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5768 104009
Ensembl ENSG00000116260 ENSMUSG00000033684
UniProt O00391 Q8BND5
RefSeq (mRNA) NM_001004128 NM_001024945
RefSeq (protein) NP_001004128 NP_001020116
Location (UCSC) Chr 1:
180.12 – 180.17 Mb
Chr 1:
155.78 – 155.81 Mb
PubMed search [1] [2]

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene.[1][2][3]

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.[3]

References[edit]

  1. ^ Coppock DL, Cina-Poppe D, Gilleran S (Feb 1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249. 
  2. ^ Coppock DL, Kopman C, Scandalis S, Gilleran S (Oct 1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ 4 (6): 483–93. PMID 8396966. 
  3. ^ a b "Entrez Gene: QSCN6 quiescin Q6". 

Further reading[edit]