Quakers Hill station opened in 1872 as Douglas Siding. It was renamed Quakers Hill on 30 March 1905 and relocated to its present location on 29 June 1939. Two sets of points at the southern end of the station allow trains to terminate on either platform.
The station had a crossing loop until the line from Marayong was duplicated to Quakers Hill in 2002. In 2011, the second track was extended to Schofields with a new overhead concourse with lists completed at the same time. As a result T5 Cumberland line services were extended to terminate at Schofields.