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Undefined Quaternium-15.png
CAS number 4080-31-3 YesY
PubChem 6435993
ChemSpider 23621565 N
Jmol-3D images Image 1
Molecular formula C9H16Cl2N4
Molar mass 251.16 g mol−1
MSDS External MSDS
EU classification Harmful XN; Highly flammable F+
R-phrases R11 R22
S-phrases S16 S36
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances. It acts as a formaldehyde releaser. It can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.

It can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.

Safety concerns[edit]

Quaternium-15 is an allergen, and can cause contact dermatitis in susceptible individuals.[1] Many of those with an allergy to quaternium-15 are also allergic to formaldehyde. Allergic sensitivity to quaternium-15 can be detected using a patch test.[2] It is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases).[3] In 2005–06, it was the fourth-most-prevalent allergen in patch tests (10.3%).[4]


  1. ^ Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. Australasia J Dermatol. 2005 Nov;46(4):284–5. PMID 16197434
  2. ^ New Zealand Dermatological Society. "Quaternium-15 contact allergy". DermNet NZ. Retrieved 2007-05-31. 
  3. ^ E. Warshaw, et al. "Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994–2004". Journal of the American Academy of Dermatology, Volume 57, Issue 2, pp. 301–314
  4. ^ Zug KA, Warshaw EM, Fowler JF Jr, Maibach HI, Belsito DL, Pratt MD, Sasseville D, Storrs FJ, Taylor JS, Mathias CG, Deleo VA, Rietschel RL, Marks J. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis. 2009 May–Jun;20(3):149-60.

See also[edit]

External links[edit]