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Systematic (IUPAC) name
(3S)-2-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Clinical data
Trade names Accupril
AHFS/Drugs.com monograph
MedlinePlus a692026
  • D
  • (Prescription only)
Pharmacokinetic data
Protein binding 97%
Half-life 2 hours
85441-61-8 YesY
PubChem CID 54892
DrugBank DB00881 YesY
ChemSpider 49565 YesY
UNII RJ84Y44811 YesY
KEGG D03752 YesY
Chemical data
Formula C25H30N2O5
438.516 g/mol
Physical data
Melting point 120 to 130 °C (248 to 266 °F)
 YesY (what is this?)  (verify)

Quinapril (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. A prodrug, it is converted to its active metabolite, quinaprilat, in the liver.

Mechanism of action[edit]

Main article: ACE inhibitor

Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a powerful vasoconstrictor and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of aldosterone are also reduced, resulting in increased excretion of sodium in the urine and increased concentrations of potassium in the blood.


Quinapril is indicated for the treatment of high blood pressure (hypertension) and as adjunctive therapy in the management of heart failure. It may be used for the treatment of hypertension by itself or in combination with thiazide diuretics, and with diuretics and digoxin for heart failure.


  • Pregnancy
  • Impaired renal and liver function
  • Patients with a history of angioedema related to previous treatment with an ACE inhibitor
  • Hypersensitivity to quinapril

Side effects[edit]

Side effects of quinapril include dizziness, cough, vomiting, upset stomach, angioedema, and fatigue.

External links[edit]