Quinazolinone

4-Quinazolinone
IUPAC name Quinazolin-4(3H)-one
Other names 4(3H)-Quinazolinone; 4(1H)-Quinazolinone; 3,4-Dihydroquinazolin-4-one; 4(3H)-Quinazolone; 4-Hydroxyquinazoline; 4-Oxo-3,4-dihydroquinazoline; 4-Oxoquinazoline; 4-Quinazolinol; 4-Quinazolinone; 4-Quinazolone
Identifiers
CAS number	491-36-1
PubChem	63112
ChemSpider	56797
ChEMBL	CHEMBL266540
Jmol-3D images	Image 1
SMILES O=C2\N=C/Nc1ccccc12
InChI InChI=InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
Properties
Molecular formula	C8H6N2O
Molar mass	146.15 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common.

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  2-Quinazolinone

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  4-Quinazolinone

Derivatives

Quinazolinones are also a class of drugs which function as hypnotic/sedatives that contain a 4-quinazolinone core. Their use has also been proposed in the treatment of cancer. Examples include afloqualone, cloroqualone, and diproqualone.

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  Methaqualone

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  Afloqualone

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  Diproqualone

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  Cloroqualone

Alkaloids containing the quinazolinone core include evodiamine, febrifugine, and halofuginone.