|Molar mass||192.17 g/mol|
|Melting point||168 °C (334 °F; 441 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Quinic acid is a cyclitol, a cyclic polyol, and a cyclohexanecarboxylic acid. It is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid. Quinic acid is also implicated in the perceived acidity of coffee. It is a constituent of the tara tannins.
This substance was isolated for the first time in the 1800s by French pharmacist Nicolas Vauquelin and further reactions from this acid to synthesize other compounds were studied by German chemist E. Lautemann in 1863.
It is soluble in water and crystallizes in large colorless prisms.
This acid is a versatile chiral starting material for the synthesis of new pharmaceuticals. A medication for the treatment of influenza A and B strains called Tamiflu has been successfully developed and launched into the market.
Quinic acid is also thought to displace binding of the mu opioid receptor antagonist; however, this acid was originally thought to be pharmacologically inactive.
- "Kinic acid". New International Encyclopedia. 1905.
- "Kinic Acid". The American Cyclopædia. 1879.
- Santos, Sónia A. O.; Freire, Carmen S. R.; Domingues, M. Rosário M.; Silvestre, Armando J. D.; Neto, Carlos Pascoal (2011). "Characterization of Phenolic Components in Polar Extracts of Eucalyptus globulus Labill. Bark by High-Performance Liquid Chromatography–Mass Spectrometry". Journal of Agricultural and Food Chemistry 59 (17): 9386–93. doi:10.1021/jf201801q. PMID 21761864.
- "Quinic acid - chiral compounds from nature - Buchler quinine plant in Braunschweig,Germany". Quinic acid. Retrieved September 5, 2005.
- "Quinic acid". Fast Health. Retrieved September 5, 2005.
- "History of Xenobiotic Metabolism". History of Xenobiotic Metabolism. Archived from the original on April 12, 2005. Retrieved September 5, 2005.