6,7-dihydropteridine reductase

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6,7-dihydropteridine reductase
EC number
CAS number 9074-11-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 6,7-dihydropteridine reductase (EC is an enzyme that catalyzes the chemical reaction

a 5,6,7,8-tetrahydropteridine + NAD(P)+ \rightleftharpoons a 6,7-dihydropteridine + NAD(P)H + H+

The 3 substrates of this enzyme are 5,6,7,8-tetrahydropteridine, NAD+, and NADP+, whereas its 4 products are 6,7-dihydropteridine, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide), reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), and 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. This enzyme participates in folate biosynthesis.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1YKI, 1YLR, and 1YLU.


  • Harano T (1972). "New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin". Insect Biochem. 2 (8): 385–399. doi:10.1016/0020-1790(72)90019-4. 
  • Hasegawa H (Tokyo). "Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH". J. Biochem. (1): 169–77. PMID 191436. 
  • Kaufman S; Bridgers, WF; Eisenberg, F; Friedman, S (1962). "Phenylalanine hydroxylase". Methods Enzymol. 5: 809–816. PMID 14031389. 
  • Lind KE (1972). "Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines". Eur. J. Biochem. 25 (3): 560–2. doi:10.1111/j.1432-1033.1972.tb01728.x. PMID 4402916. 
  • Nakanishi N, Hasegawa H, Watabe S (Tokyo). "A new enzyme, NADPH-dihydropteridine reductase in bovine liver". J. Biochem. (3): 681–5. PMID 16875.