During the twelfth century the Hospitallers established an administrative and collection centre in the village, comprising a tower and a vaulted structure.
In 1596, Qula was part of the Ottoman Empire, nahiya (subdistrict) of al-Ramla under the Liwa of Gaza, with a population of 380. It paid taxes on goats and beehives, and a press that was used for processing either olives or grapes.
In the late nineteenth century, the village of Qula was described as being situated on a slope at the edge of a plain; its historical relics dating back to medieval times. The village mosque stood approximately 10m east of the Crusader tower. It comprised a large vaulted iwan and a smaller room with an inscription above the entrance.
During the British mandate period, the village expanded along the Ramle-Tulkarm highway. In the village center was the mosque, several small shops, and a school which had been founded in 1919. By the mid-1940s the school had 134 students. In 1944/45 the villagers used a total of 2,842 dunums of land for cereals, while 105 dunums were irrigated or used for orchards.
Most of the villagers fled in 1948, leaving only a few, primarily elderly behind. The villagers from Qula report that those left behind (six women and one man) were all shot or burned to death in their homes.
A Jewish War Memorial, Givat Koach, now occupies the land where Qula once was.
The Palestinian historian Walid Khalidi described the village site in 1992: "A forest covers much of the village site. The rubble of crumbled houses and terraces lies among the trees, and cactuses and fig, mulberry, and eucalyptus trees grow there as well. The only remaining landmark is the school, on the west side of the site. The hilly parts of the surrounding land are used for grazing animals; the rest of the land is cultivated.
Hütteroth, Wolf-Dieter; Abdulfattah, Kamal (1977). Historical Geography of Palestine, Transjordan and Southern Syria in the Late 16th Century. Erlanger Geographische Arbeiten, Sonderband 5. Erlangen, Germany: Vorstand der Fränkischen Geographischen Gesellschaft. ISBN3-920405-41-2.
Pringle, R. D. (1986), The Red Tower (al-Burj al-Ahmar): Settlement in the Plain of Sharon at the Time of the Crusaders and Mamluks, A.D. 1099-1516, British School of Archeology in Jerusalem Monograph Series, No. 1, London. (Cited in Petersen, 2001)