R. Graham Cooks

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Robert Graham Cooks
Residence United States
Nationality United States
Fields Chemist
Institutions Purdue University
Alma mater University of Natal
Cambridge University
Doctoral advisor Frank L. Warren
Peter Sykes
Known for Mass Spectrometry

Robert Graham Cooks is the Henry Bohn Hass Distinguished Professor of Chemistry at Purdue University. He is an ISI Highly Cited Chemist,[1] with over 950 publications and an H-index of 81.[2]

Early life and education[edit]

He received his B.S. from University of Natal, South Africa in 1961; his Ph.D. from University of Natal, South Africa in 1965; and his Ph.D. from Cambridge University, Great Britain in 1967.

Research interests[edit]

Research in Cooks' laboratory (the Aston Laboratory) has contributed to a diverse assortment of areas within mass spectrometry, ranging from fundamental research to instrument and method development to applications. Cooks' research interests over the course of his career have included the following (citations are representative): the study of gas-phase ion reactions (e.g., unimolecular reactions of activated radical ions,[3][4][5] metastable decay,[6][7] ion/molecule reactions,[8][9][10] and charge exchange reactions [11][12][13]); early developments in tandem mass spectrometry (e.g., complex mixture analysis[14][15][16][17] and instrumentation[18][19][20]); Mass-Analyzed Ion Kinetic Energy Spectroscopy (MIKES);[21][22] kinetic isotope effects;[23][24][25] the Kinetic Method for thermochemical determinations;[26][27][28] Angle-Resolved Mass Spectrometry;[29][30] Energy-Resolved Mass Spectrometry (ERMS);[31][32] chiral analysis;[33][34] ion activation/dissociation processes (collision-induced dissociation (CID),[35][36][37] surface-induced dissociation (SID),[38][39] and photodissociation (PD) [40]); desorption/ionization processes (e.g., secondary ion mass spectrometry (SIMS),[41][42][43] laser desorption ionization (LD),[44] and desorption electrospray ionization (DESI) [45][46]); preparative mass spectrometry (‘ion soft-landing’ and related phenomena);[47][48][49] ionization techniques (Matrix-Enhanced Laser Desorption,[50] DESI,[51][52] Atmospheric Pressure Thermal Desorption/Ionization (APTDI),[53] Low Temperature Plasma (LTP),[54] Paper Spray,[55][56] and Leaf Spray [57]); the development of quadrupole ion traps (QITs) and related technologies (e.g., ion injection into QITs,[58] broadband isolation/excitation,[59] resonance ejection,[60] high mass resolution,[61] ion cloud tomography,[62] the Cylindrical Ion Trap (CIT),[63] and the Rectilinear Ion Trap (RIT) [64]); trapped ion motion phenomena and simulations;[65][66][67] Membrane Introduction Mass Spectrometry (MIMS);[68] the origin of life (homochirality);[69][70] chemical imaging;[71][72][73] the development of portable mass spectrometers or miniature mass spectrometers [74] and related technologies.[75][76]

Awards and Fellowships[edit]

See also[edit]


  1. ^ [1][dead link]
  2. ^ "H-index ranking of living chemists" (PDF). December 2011. Retrieved 2015-03-27. 
  3. ^ D.H. Williams and R.G. Cooks, "The Role of 'Frequency Factors' in Determining the Difference Between Low and High Voltage Mass Spectra", Chem. Commun., (1968) 663. doi:10.1039/C19680000663
  4. ^ R.G. Cooks, "Bond Formation Upon Electron Impact", Org. Mass Spectrom., 2 (5) (1969) 481 doi:10.1002/oms.1210020505
  5. ^ R.G. Cooks and S.L. Bernasek, "Carbon Scrambling Upon Electron Impact", J. Amer. Chem. Soc., 92 (7) (1970) 2129 doi:10.1021/ja00710a055
  6. ^ R. G. Cooks, J. H. Beynon, R. M. Caprioli, G. R. Lester Metastable Ions. Elsevier, Amsterdam, 1973. pp. ix + 296.
  7. ^ D.T. Terwilliger, J.F. Elder, J.H. Beynon and R.G. Cooks, "The Shapes of Metastable Peaks", Int. J. Mass Spectrom. Ion Phys., 16 (3) (1975) 225 doi:10.1016/0020-7381(75)87022-7
  8. ^ D.J. Burinsky and R.G. Cooks, "Gas Phase Dieckmann Ester Condensation Characterized by Mass Spectrometry/Mass Spectrometry", J. Org. Chem., 47 (25) (1982) 4864-4869 doi:10.1021/jo00146a009
  9. ^ D.J. Burinsky, J.E. Campana and R.G. Cooks, "Bimolecular Condensation Reactions in the Gas Phase. The Schiff Base Synthesis", Int. J. Mass Spectrom. Ion Proc., 62 (3) (1984) 303-315 doi:10.1016/0168-1176(84)87117-7
  10. ^ Hao Chen, Huanwen Chen and R. Graham Cooks, "Meisenheimer Complexes Bonded at Carbon and at Oxygen in the Gas Phase", J. Am. Soc. Mass Spectrom., 2004, 15, 998-1004. doi:10.1016/j.jasms.2004.03.006
  11. ^ R.G. Cooks, J.H. Beynon and T. Ast, "Stripping Reactions of Gaseous Ions in the Mass Spectrometer", J. Amer. Chem. Soc., 94 (3) (1972) 1004 doi:10.1021/ja00758a055
  12. ^ J.A. LaramÆe, D. Cameron and R.G. Cooks, "Collision Induced Dissociation Mass Spectrometry: Target Gas Effects upon Scattering and Charge Exchange", J. Am. Chem. Soc., 103 (1) (1981) 12-17 doi:10.1021/ja00391a003
  13. ^ M.E. Bier, M. Vincenti, R.G. Cooks and T. Keough, "Ion/Surface Collisions Which Lead to Charge Permutation", Rapid Communications in Mass Spectrometry, 1 (1987) 92-94 doi:10.1002/rcm.1290010604
  14. ^ T.L. Kruger, J.F. Litton, R.W. Kondrat, and R.G. Cooks. Mixture Analysis by Mass-Analyzed Ion Kinetic Energy Spectrometry. Anal. Chem. 1976. 48(14): 2113-2119. doi:10.1021/ac50008a016
  15. ^ R.W. Kondrat and R.G. Cooks, "Direct Analysis of Mixtures by Mass Spectrometry", Anal. Chem., 50 (1)(1978) A81 doi:10.1021/ac50023a006
  16. ^ G.L. Glish, V.M. Shaddock, K. Harmon and R.G. Cooks, "Rapid Analysis of Complex Mixtures by Mass Spectrometry/Mass Spectrometry", Anal. Chem., 52 (1) (1980) 165-167 doi:10.1021/ac50051a038
  17. ^ Cooks, Robert (1978). "Multiple Reaction Monitoring in Mass Spectrometry/Mass Spectrometry for Direct Analysis of Complex Mixtures". Analytical Chemistry 50 (14): 2017–2021. doi:10.1021/ac50036a020. 
  18. ^ L.G. Wright, J.C. Schwartz and R.G. Cooks, "Hybrid Mass Spectrometers: Versatile Research Instruments", Trends Anal. Chem., 5 (1986) 236-240 doi:10.1016/0165-9936(86)85061-0
  19. ^ Schey, R.G. Cooks, R. Grix and H. Wollnik, "A Tandem Time-of-Flight Mass Spectrometer for Surface Induced Dissociation", Int. J. Mass Spectrom. Ion Proc., 77 (1) (1987) 49-61 doi:10.1016/0168-1176(87)83023-9
  20. ^ J. C. Schwartz, A. P. Wade, C. G. Enke and R.G. Cooks, "Systematic Delineation of Scan Modes in Multidimensional Mass Spectrometry", Anal. Chem. 62, (1990) 11809 - 1818 doi:10.1021/ac00216a016
  21. ^ J.H. Beynon, R.G. Cooks, J.W. Amy, W.E. Baitinger and T.Y. Ridley, "Design and Performance of a Mass-Analyzed Ion Kinetic Energy Spectrometer", Anal. Chem., 45, (1973) 1023A.
  22. ^ D. Zakett, V.M. Shaddock and R.G. Cooks, "Analysis of Coal Liquids by Mass-Analyzed Ion Kinetic Energy Spectrometry", Anal. Chem., 51 (11) (1979) 1849 doi:10.1021/ac50047a054
  23. ^ M. Bertrand, J.H. Beynon and R.G. Cooks, "Isotope Effects Upon Kinetic Energy Release in Metastable Ion Fragmentations", Int. J. Mass Spectrom. Ion Phys., 9, (1972) 346.
  24. ^ D. Zakett, R.G.A. Flynn and R.G.Cooks, "Chlorine Isotope Effects in Mass Spectrometry by Multiple Reaction Monitoring", J. Phys. Chem., 82 (22) (1978) 2359 doi:10.1021/j100511a002
  25. ^ Jason R. Green and R. Graham Cooks, "Inverse Heavy-Atom Kinetic Isotope Effects in Chloroalkanes" J. Phys. Chem. A 2004, 108 (46), 10039-10043. doi:10.1021/jp046228g
  26. ^ R.G. Cooks, and T.L. Kruger, "Intrinsic Basicity Determination Using Metastable Ions", J. Amer. Chem. Soc., 99(4) (1977) 1279 doi:10.1021/ja00446a059
  27. ^ R. G. Cooks, J. T. Koskinen and P. D. Thomas, "The Kinetic Method of Making Thermochemical Determinations", Journal of Mass Spectrometry 34(2), 85-92 (1999). doi:10.1002/(SICI)1096-9888(199902)34:2<85::AID-JMS795>3.0.CO;2-#
  28. ^ X. Zheng and R. Graham Cooks, "Thermochemical Determinations by the Kinetic Method with Direct Entropy Correction", J. Phys. Chem. A 2002, 106, 9939 - 9946 doi:10.1021/jp020595f
  29. ^ J.A. Laramee, J. Carmody and R.G. Cooks, "Angle Resolved Mass Spectrometry", Int. J. Mass Spectrom. and Ion Phys., 31 (4) (1979) 333 doi:10.1016/0020-7381(79)80071-6
  30. ^ A.R. Hubik, P.H. Hemberger, J.A. LaramÆe and R.G. Cooks, "Control of Energy Deposition by Impact Parameter in Polyatomic Ion Collisions", J. Am. Chem. Soc., 102, (1980) 3997- 4000 doi:10.1021/ja00532a003
  31. ^ S.A. McLuckey, L. Sallans, R.G. Cody, R.C. Burnier, S. Verma, B.S. Freiser and R.G. Cooks, "Energy-Resolved Tandem and Fourier-Transform Mass Spectrometry", Int. J. Mass Spectrom. Ion Phys., 44 (3-4) (1982) 215-229 doi:10.1016/0020-7381(82)80026-0
  32. ^ H.I. KenttÆmaa and R.G. Cooks, "Tautomer Characterization by Energy Resolved Mass Spectrometry. Dimethyl Phosphite and Dimethyl Phosphonate Ions", J. Amer. Chem. Soc., 107 (1985) 1881-1886 doi:10.1021/ja00293a013
  33. ^ W. Andy Tao and R. Graham Cooks, "Chiral Analysis by Mass Spectrometry" Anal. Chem. 75, 25A – 31A (2003), doi:10.1021/ac0312110
  34. ^ Brandy L. Young and R. Graham Cooks, "Improvements in Quantitative Chiral Determinations using the Mass Spectrometric Kinetic Method",International Journal of Mass Spectrometry,2007, 267, 1-3,199-204, doi:10.1016/j.ijms.2007.02.036
  35. ^ J.S. Brodbelt, V.H. Wysocki and R.G. Cooks, "Thermochemical vs. Kinetic Control of Reaction in an Ion Trap Mass Spectrometer", Org. Mass Spectrom., 23 (1) (1988) 54-56 doi:10.1002/oms.1210230111
  36. ^ V.H. Wysocki, M.M. Ross, S.R. Horning and R.G. Cooks, "Remote-Site (Charge-Remote) Fragmentation", Rapid Commun. Mass Spectrom., 2 (1988) 214-216 doi:10.1002/rcm.1290021009
  37. ^ R. G. Cooks, "Collision-induced Dissociation: Readings and Commentary", J. Mass Spectrom. 30, (1995) 1215- 1221.
  38. ^ B.E. Winger, R.K. Julian, Jr., R.G. Cooks and C.E.D. Chidsey, "Surface Reactions and Surface-Induced Dissociation of Polyatomic Ions at Self-Assembled Organic Monolayer Surfaces", J. Am. Chem. Soc., 113 (1991) 8967 -8969 doi:10.1021/ja00023a067
  39. ^ R.G. Cooks, T. Ast, T. Pradeep and V. Wysocki, "Reactions of Ions with Organic Surfaces", Accounts Chem. Res., 27 (1994) 316, doi:10.1021/ar00047a001
  40. ^ J.N. Louris, J.S. Brodbelt and R.G. Cooks, "Photodissociation in a Quadrupole Ion Trap Mass Spectrometer Using a Fiber Optic Interface", Int. J. Mass Spectrom. Ion Proc., 75 (3) (1987) 345-352 doi:10.1016/0168-1176(87)83045-8
  41. ^ H. Grade, N. Winograd and R.G. Cooks, "Cationization of Organic Molecules in Secondary Ion Mass Spectrometry", J. Amer. Chem. Soc., 99 (23) (1977) 7725 doi:10.1021/ja00465a062
  42. ^ K.L. Busch and R.G. Cooks, "Mass Spectrometry of Large, Fragile and Involatile Molecules", Science, 218, (1982) 247-254 doi:10.1126/science.218.4569.247
  43. ^ S.J. Pachuta and R.G. Cooks, "Mechanism in Molecular SIMS", Chem. Rev., 87 (3) (1987) 647- 669 doi:10.1021/cr00079a009
  44. ^ D. Zakett, A.E. Schoen, R.G. Cooks and P.H. Hemberger, "Laser-Desorption Mass Spectrometry/Mass Spectrometry and the Mechanism of Desorption Ionization", J. Am. Chem. Soc., 103 (5) (1981) 1295-1297 doi:10.1021/ja00395a086
  45. ^ Anthony B. Costa, R. Graham Cooks, "Simulation of Atmospheric Transport and Droplet Thin-Film Collisions in Desorption Electrospray Ionization",Chemical Communications,2007,3915-3917, doi:10.1039/b710511h
  46. ^ Anthony B Costa, R. Graham Cooks, "Simulated Splashes: Elucidating the Mechanism of Desorption Electrospray Ionization Mass Spectrometry",Chemical Physics Letters,2008, 464,1-8, doi:10.1016/j.cplett.2008.08.020
  47. ^ R. Graham Cooks, Sung-Chan Jo and Jason R. Green, "Collisions of Organic Ions at Surfaces" Appl. Surf. Sci., 231-232 (2004), 13-21. doi:10.1016/j.apsusc.2004.03.017
  48. ^ Zongxiu Nie, Guangtao Li, Michael P. Goodwin, Liang Gao, Jobin Cyriac, R. Graham Cooks, "In situ SIMS Analysis and Reactions of Surfaces after Soft-Landing of Mass-selected Cations and Anions in an Ion Trap Mass Spectrometer",Journal of the American Society of Mass Spectrometry,2009, 20(6),949-956, doi:10.1016/j.jasms.2009.02.019
  49. ^ Ryan D. Espy, Abraham Badu-Tawiah, R. Graham Cooks, "Analysis and Modification of Surfaces using Molecular Ions in the Ambient Environment",Current Opinions in Chemical Biology,2011, 15,741-747, doi:10.1016/j.cbpa.2011.06.006
  50. ^ L.G. Wright, R.G. Cooks and K.V. Wood, "Matrix Enhanced Laser Desorption in Mass Spectrometry and Tandem Mass Spectrometry", Biomed. Mass Spectrom., 12(4) (1985) 159- 162. doi:10.1002/bms.1200120404
  51. ^ R. Graham Cooks, Zheng Ouyang, Zoltan Takats, Justin M. Wiseman, "Ambient Mass Spectrometry", Science, 2006, 311(5767),1566-1570, doi:10.1126/science.1119426
  52. ^ Andre Venter, Marcela Nefliu, R. Graham Cooks, "Ambient Desorption Ionization Mass Spectrometry",Trends in Analytical Chemistry,2008, 27,284-290, doi:10.1016/j.trac.2008.01.010
  53. ^ H. Chen, L. S. Eberlin, M. Nefliu, R. Augusti, R. G. Cooks, "Organic Reactions of Ionic Intermediates Promoted by Atmospheric-Pressure Thermal Activation",Angewandte Chemie International Edition,2008, 47,3422-3425, doi:10.1002/anie.200800072
  54. ^ Jason D. Harper, Nicholas A.Charipar, Christopher C. Mulligan, R. Graham Cooks, and Zheng Ouyang, "Low Temperature Plasma Probe for Ambient Desorption Ionization",Analytical Chemistry,2008, 80,9097-9104, doi:10.1021/ac801641a
  55. ^ He Wang, Jiangjiang Liu, R. Graham Cooks, Zheng Ouyang, "Paper Spray for Direct Analysis of Complex Mixtures using Mass Spectrometry",Angewandte Chemie International Edition,2009, doi:10.1002/anie.200906314
  56. ^ Nicholas E. Manicke, Paul Abu-Rabie, Neil Spooner, Zheng Ouyang and R. Graham Cooks, "Quantitative Analysis of Therapeutic Drugs in Dried Blood Spot Samples by Paper Spray Mass Spectrometry: An Avenue to Therapeutic Drug Monitoring",Journal of the American Society of Mass Spectrometry,2011, in press, doi:10.1007/s13361-011-0177-x
  57. ^ Jiangjiang Liu, He Wang, R. Graham Cooks, and Zheng Ouyang, "Leaf Spray: Direct Chemical Analysis of Plant Material and Living Plants by Mass Spectrometry",Analytical Chemistry,2011, 83,7608-7613, doi:10.1021/ac2020273
  58. ^ J.N. Louris, J.W. Amy, T.Y. Ridley and R.G. Cooks, "Injection of Ions Into a Quadrupole Ion Trap Mass Spectrometer", Int. J. Mass Spectrom. Ion Proc., 88 (2-3) (1989) 97-111 doi:10.1016/0168-1176(89)85010-4
  59. ^ M. Soni, V. Frankevich, M. Nappi, R. E. Santini, J. W. Amy and R. G. Cooks, "Broad- Band Fourier Transform Quadrupole Ion Trap Mass Spectrometry", Anal. Chem. 68 (1996) 3314-3320, doi:10.1021/ac960577s
  60. ^ J.D. Williams, K.A. Cox, R.G. Cooks, S.A. McLuckey, K.J. Hart and D.E. Goeringer, "Resonance Ejection Ion Trap Mass Spectrometry and Non-Linear Field Contributions: The Effect of Scan Direction on Mass Resolution", Anal. Chem., 66 (1994) 725 doi:10.1021/ac00077a023
  61. ^ J.D. Williams, K.A. Cox, R.E. Kaiser, Jr. and R.G. Cooks, "High Mass-Resolution Using a Quadrupole Ion Trap Mass Spectrometer", Rapid Commun. Mass Spectrom., 5 (1991) 327- 329 doi:10.1002/rcm.1290050706
  62. ^ P.H. Hemberger, N.S. Nogar, J.D. Williams, R.G. Cooks, and J.E.P. Syka, "Laser Photodissociation Probe for Ion Tomography Studies in a Quadrupole Ion Trap Mass Spectrometer", Chem. Phys. Letters, 191 (1992) 405 doi:10.1016/0009-2614(92)85400-5
  63. ^ M. Wells, E. R. Badman and R. G. Cooks, "A Quadrupole Ion Trap with Cylindrical Geometry Operated in the Mass-Selective Instability Mode" Anal. Chem. 70(3) 438 - 444 (1998) doi:10.1021/ac971198h
  64. ^ Zheng Ouyang, Guangxiang Wu, Yishu Song, Hongyan Li, Wolfgang R. Plass, and R. Graham Cooks, "Rectilinear Ion Trap: Concepts, Calculations, and Analytical Performance of a New Mass Analyzer" Anal. Chem. 76 (2004) 4595 -4605. doi:10.1021/ac049420n
  65. ^ H. A. Bui and R. G. Cooks, "Windows Version of the Ion Trap Simulation Program, ITSIM: A Powerful Heuristic and Predictive Tool in Ion Trap Mass Spectrometry" J. Mass Spectrom. 33, 297-304 (1998) doi:10.1002/(SICI)1096-9888(199804)33:4<297::AID-JMS665>3.0.CO;2-V
  66. ^ Wolfgang R. Plass, Hongyan Li, and R. Graham Cooks, "Theory, Simulation and Measurement of Chemical Mass Shifts in RF Quadrupole Ion Traps", Int. J. Mass Spectrom. (2003), 228, 237-267. doi:10.1016/S1387-3806(03)00216-1
  67. ^ Guangxiang Wu, Robert J. Noll, Wolfgang R. Plass, Qizhi Hu, Richard H. Perry, and R. Graham Cooks, "Ion Trajectory Simulations of Axial AC Dipolar Excitation in the Orbitrap",International Journal of Mass Spectrometry,2006, 254, 1-2,53-62, doi:10.1016/j.ijms.2006.05.007
  68. ^ T. Kotiaho, F.R. Lauritsen, T.K. Choudhury and R.G. Cooks, "Membrane Introduction Mass Spectrometry", Anal. Chem., 63 (18) (1991) 875 doi:10.1021/ac00018a001
  69. ^ Pengxiang Yang, Ruifeng Xu, Sergio C. Nanita, and R. Graham Cooks, "Thermal Formation of Homochiral Serine Clusters and Implications for the Origin of Homochirality",Journal of the American Chemical Society,2006, 128(51),17074-17086, doi:10.1021/ja064617d
  70. ^ Perry, R. H., Wu, C., Nefliu, M., and Cooks, R. G., "Serine Sublimes with Spontaneous Chiral Amplification",Chemical Communications,2007,1071-1073, doi:10.1039/b616196k
  71. ^ J.M. Wiseman, D.R. Ifa, A. Venter, R.G. Cooks, "Ambient molecular imaging by desorption electrospray ionization mass spectrometry",Nature Protocols,2008, 3(3),517-524, doi:10.1038/nprot.2008.11
  72. ^ Livia S. Eberlin, Demian R. Ifa, Chunping Wu, R. Graham Cooks, "Three-Dimensional Vizualization of Mouse Brain by Lipid Analysis Using Ambient Ionization Mass Spectrometry",Angewandte Chemie International Edition,2010, 49,873-876, doi:10.1002/anie.200906283
  73. ^ Allison L. Dill, Livia S. Eberlin, Demian R. Ifa and R. Graham Cooks, "Perspectives in Imaging using Mass Spectrometry",Chemical Communications,2011, 47,2741-2746, doi:10.1039/C0CC03518A
  74. ^ Santosh Soparawalla, Fatkhulla K. Tadjimukhamedov, Joshua S. Wiley, Zheng Ouyang and R. Graham Cooks, "In situ analysis of agrochemical residues on fruit using ambient ionization on a handheld mass spectrometer" , Analyst , 2011 , 136, 4392 -4396, doi:10.1039/C1AN15493A
  75. ^ Zheng Ouyang, Robert J. Noll, R. Graham Cooks, "Handheld Miniature Ion Trap Mass Spectrometers",Analytical Chemistry,2009, 81 (7),2421-2425, doi:10.1021/ac900292w
  76. ^ Zheng Ouyang and R. Graham Cooks, "Miniature Mass Spectrometers",Annual Review of Analytical Chemistry,2009, 2,187-214, doi:10.1146/annurev-anchem-060908-155229
  77. ^ Glish G (2008). "Focus Honoring R. Graham Cooks, Recipient of the 2006 ASMS Award for Distinguished Contribution in Mass Spectrometry". J. Am. Soc. Mass Spectrom. 19 (2): 159–60. doi:10.1016/j.jasms.2007.11.011. PMID 18160305. 

External links[edit]