Originally the R27 designation continued beyond Upington all the way to Pretoria, but this section became part of the N14 and various other roads.
In Cape Town the highway connects with Table Bay Boulevard (N1) near the Table Bay Harbor and then runs north along the coast for stretch that is known as Marine Drive. This stretch contains many industrial warehouses. Later the road moves further inland and the M14 becomes the main coastal road. Further north the road passes through West Coast National Park before reaching Velddrif.
The northern segment of the road is exceptionally desolate; it is a distance of 370 kilometres (230 mi) from Calvinia to Keimoes, and the only towns along the way are Brandvlei and Kenhardt.
View from Vanrhyns Pass, a section of the R27 on the Bokkeveld Escarpment. In the valley below the road continues to Vanrhynsdorp, with the Knersvlakte region to the right.