RAB11FIP1

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RAB11 family interacting protein 1 (class I)
Identifiers
Symbols RAB11FIP1 ; NOEL1A; RCP; rab11-FIP1
External IDs OMIM608737 MGI1923017 HomoloGene11853 GeneCards: RAB11FIP1 Gene
RNA expression pattern
PBB GE RAB11FIP1 219681 s at tn.png
PBB GE RAB11FIP1 gnf1h08115 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 80223 75767
Ensembl ENSG00000156675 ENSMUSG00000031488
UniProt Q6WKZ4 Q9D620
RefSeq (mRNA) NM_001002233 NM_001080813
RefSeq (protein) NP_001002814 NP_001074282
Location (UCSC) Chr 8:
37.72 – 37.76 Mb
Chr 8:
27.14 – 27.17 Mb
PubMed search [1] [2]

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.[1][2][3]

Function[edit]

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.[2][3] RAB11FIP1 has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the adipocyte.[4] RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.[4]

Interactions[edit]

RAB11FIP1 has been shown to interact with RAB11A[1][2][5] and RAB4A.[1]

References[edit]

  1. ^ a b c Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538. 
  2. ^ a b c Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908. 
  3. ^ a b "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)". 
  4. ^ a b Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLoS ONE 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMID 24040321. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]