RAB22A

RAB22A, member RAS oncogene family
PDB rendering based on 1yvd.
Available structures PDB 1yvd, 1z0j
Identifiers
Symbols	RAB22A; MGC16770
External IDs	OMIM: 612966 MGI: 105072 HomoloGene: 10782 GeneCards: RAB22A Gene
Gene Ontology Molecular function • nucleotide binding • GTPase activity • protein binding • GTP binding Cellular component • early endosome • plasma membrane • endosome membrane Biological process • GTP catabolic process • endocytosis • endosome organization • small GTPase mediated signal transduction • protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57403	19334
Ensembl	ENSG00000124209	ENSMUSG00000027519
UniProt	Q9UL26	Q0PD34
RefSeq (mRNA)	NM_020673	NM_024436.3
RefSeq (protein)	NP_065724	NP_077756.2
Location (UCSC)	Chr 20: 56.88 – 56.94 Mb	Chr 2: 173.49 – 173.53 Mb
PubMed search	[1]	[2]

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.

Further reading

• Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381. 
• Bucci C, Chiariello M, Lattero D et al (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441. 
• Opdam FJ, Kamps G, Croes H et al (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961. 
• Deloukas P, Matthews LH, Ashurst J et al (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–871. doi:10.1038/414865a. PMID 11780052. 
• Kauppi M, Simonsen A, Bremnes B et al (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell. Sci. 115 (Pt 5): 899–911. PMID 11870209. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=491835. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Mesa R, Magadán J, Barbieri A et al (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153. 
• Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
• Magadán JG, Barbieri MA, Mesa R et al (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1430328.