RAB25

RAB25, member RAS oncogene family
PDB rendering based on 2oil.
Available structures PDB 2oil
Identifiers
Symbols	RAB25; CATX-8; RAB11C
External IDs	OMIM: 612942 MGI: 1858203 HomoloGene: 22995 GeneCards: RAB25 Gene
Gene Ontology Molecular function • nucleotide binding • protein binding • GTP binding • identical protein binding Cellular component • cytoplasm • plasma membrane • cytoplasmic membrane-bounded vesicle • pseudopodium • pseudopodium membrane • cytoplasmic vesicle Biological process • small GTPase mediated signal transduction • positive regulation of cell proliferation • protein transport • pseudopodium organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57111	53868
Ensembl	ENSG00000132698	ENSMUSG00000008601
UniProt	P57735	Q0PD30
RefSeq (mRNA)	NM_020387	NM_016899.4
RefSeq (protein)	NP_065120	NP_058595.2
Location (UCSC)	Chr 1: 156.03 – 156.04 Mb	Chr 3: 88.35 – 88.35 Mb
PubMed search	[1]	[2]

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.

Interactions

RAB25 has been shown to interact with RAB11FIP2 and RAB11FIP5.

Further reading

• Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung.". J. Biol. Chem. 268 (25): 18419–22. PMID 8360141. 
• Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.". Lab. Invest. 77 (5): 503–11. PMID 9389793. 
• Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems.". Mol. Biol. Cell 12 (6): 1843–57. PMC 37346. PMID 11408590. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37346. 
• Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332. 
• Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins.". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908. 
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311163. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.". Pathology 38 (6): 561–7. doi:10.1080/00313020601024037. PMID 17393986.