RAB27A

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RAB27A, member RAS oncogene family
Identifiers
Symbols RAB27A ; GS2; HsT18676; RAB27; RAM
External IDs OMIM603868 MGI1861441 HomoloGene3069 GeneCards: RAB27A Gene
RNA expression pattern
PBB GE RAB27A 209514 s at tn.png
PBB GE RAB27A 209515 s at tn.png
PBB GE RAB27A 210951 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5873 11891
Ensembl ENSG00000069974 ENSMUSG00000032202
UniProt P51159 Q9ERI2
RefSeq (mRNA) NM_004580 NM_023635
RefSeq (protein) NP_004571 NP_076124
Location (UCSC) Chr 15:
55.5 – 55.61 Mb
Chr 9:
73.04 – 73.1 Mb
PubMed search [1] [2]

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.[1][2]

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]

The RAB27A gene is regulated by the Microphthalmia-associated transcription factor.[3][4]

Interactions[edit]

RAB27A has been shown to interact with EXPH5,[5] SYTL1,[5][6][7] MYO5A,[8][9] RPH3AL[10][11] and SYTL2.[5][6][7]

See also[edit]

References[edit]

  1. ^ Seabra MC, Ho YK, Anant JS (Dec 1995). "Deficient geranylgeranylation of Ram/Rab27 in choroideremia". J Biol Chem 270 (41): 24420–7. doi:10.1074/jbc.270.41.24420. PMID 7592656. 
  2. ^ a b "Entrez Gene: RAB27A RAB27A, member RAS oncogene family". 
  3. ^ Chiaverini C, Beuret L, Flori E, Busca R, Abbe P, Bille K, Bahadoran P, Ortonne JP, Bertolotto C, Ballotti R (2008). "Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport". J. Biol. Chem. 283 (18): 12635–42. doi:10.1074/jbc.M800130200. PMID 18281284. 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ a b c Kuroda, Taruho S; Fukuda Mitsunori; Ariga Hiroyoshi; Mikoshiba Katsuhiko (Mar 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. (United States) 277 (11): 9212–8. doi:10.1074/jbc.M112414200. ISSN 0021-9258. PMID 11773082. 
  6. ^ a b Fukuda, Mitsunori (Apr 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. (United States) 278 (17): 15390–6. doi:10.1074/jbc.M213090200. ISSN 0021-9258. PMID 12590134. 
  7. ^ a b Strom, Molly; Hume Alistair N; Tarafder Abul K; Barkagianni Eleni; Seabra Miguel C (Jul 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. (United States) 277 (28): 25423–30. doi:10.1074/jbc.M202574200. ISSN 0021-9258. PMID 11980908. 
  8. ^ Wu, Xufeng; Wang Fei; Rao Kang; Sellers James R; Hammer John A (May 2002). "Rab27a is an essential component of melanosome receptor for myosin Va". Mol. Biol. Cell (United States) 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. ISSN 1059-1524. PMC 111140. PMID 12006666. 
  9. ^ Nagashima, Kazuaki; Torii Seiji; Yi Zhaohong; Igarashi Michihiro; Okamoto Koichi; Takeuchi Toshiyuki; Izumi Tetsuro (Apr 2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. (Netherlands) 517 (1–3): 233–8. doi:10.1016/S0014-5793(02)02634-0. ISSN 0014-5793. PMID 12062444. 
  10. ^ Cheviet, Séverine; Coppola Thierry; Haynes Lee P; Burgoyne Robert D; Regazzi Romano (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. (United States) 18 (1): 117–26. doi:10.1210/me.2003-0300. ISSN 0888-8809. PMID 14593078. 
  11. ^ Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. (United States) 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829. 

Further reading[edit]