RAB5C

RAB5C, member RAS oncogene family
	; PDB rendering based on 1huq.
Available structures
PDB	1huq, 1n6h, 1n6i, 1n6k, 1n6l, 1n6n, 1n6o, 1n6p, 1n6r, 1r2q, 1tu3, 1tu4, 1z07, 1z0d
Identifiers
Symbols	RAB5C; L1880; RAB5CL; RAB5L; RABL
External IDs	OMIM: 604037 MGI: 105306 HomoloGene: 55533 GeneCards: RAB5C Gene
Gene Ontology
Molecular function	• nucleotide binding; • GTPase activity; • GTP binding;
Cellular component	• endosome; • plasma membrane; • endocytic vesicle; • cytoplasmic vesicle; • early endosome membrane; • melanosome;
Biological process	• GTP catabolic process; • endosome organization; • small GTPase mediated signal transduction; • protein transport; • regulation of endocytosis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

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Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.^[1]^[2] RAB5C belongs to the Ras-related protein family.

[edit] References

^ Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet 73 (1-2): 137–9. doi:10.1159/000134325. PMID 8646882.
^ "Entrez Gene: RAB5C RAB5C, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5878.

[edit] Further reading

Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316.
Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells.". J. Biol. Chem. 273 (51): 33901–4. doi:10.1074/jbc.273.51.33901. PMID 9852039.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC 97474. PMID 10768959. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=97474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.