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RAB6A, member RAS oncogene family
Protein RAB6A PDB 1yzq.png
PDB rendering based on 1yzq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAB6A ; RAB6
External IDs OMIM179513 MGI894313 HomoloGene55697 GeneCards: RAB6A Gene
RNA expression pattern
PBB GE RAB6A 210406 s at tn.png
PBB GE RAB6A 201045 s at tn.png
PBB GE RAB6A 201047 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5870 19346
Ensembl ENSG00000175582 ENSMUSG00000030704
UniProt P20340 P35279
RefSeq (mRNA) NM_001243718 NM_001163663
RefSeq (protein) NP_001230647 NP_001157135
Location (UCSC) Chr 11:
73.39 – 73.47 Mb
Chr 7:
100.61 – 100.64 Mb
PubMed search [1] [2]

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene.[1]


RAB6A has been shown to interact with ERC1,[2] KIF20A,[3][4] DCTN1[5] and BICD1.[5][6]


  1. ^ "Entrez Gene: RAB6A RAB6A, member RAS oncogene family". 
  2. ^ Monier, Solange; Jollivet Florence, Janoueix-Lerosey Isabelle, Johannes Ludger, Goud Bruno (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic (Denmark) 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. ISSN 1398-9219. PMID 11929610. 
  3. ^ Echard, A; Jollivet F, Martinez O, Lacapère J J, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science (UNITED STATES) 279 (5350): 580–5. doi:10.1126/science.279.5350.580. ISSN 0036-8075. PMID 9438855. 
  4. ^ Echard, A; Opdam F J, de Leeuw H J, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen J A (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell (UNITED STATES) 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. ISSN 1059-1524. PMC 15039. PMID 11071909. 
  5. ^ a b Short, Benjamin; Preisinger Christian, Schaletzky Julia, Kopajtich Robert, Barr Francis A (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. (England) 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. ISSN 0960-9822. PMID 12401177. 
  6. ^ Matanis, Theodoros; Akhmanova Anna, Wulf Phebe, Del Nery Elaine, Weide Thomas, Stepanova Tatiana, Galjart Niels, Grosveld Frank, Goud Bruno, De Zeeuw Chris I, Barnekow Angelika, Hoogenraad Casper C (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. (England) 4 (12): 986–92. doi:10.1038/ncb891. ISSN 1465-7392. PMID 12447383. 

Further reading[edit]