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RAB6A, member RAS oncogene family
Protein RAB6A PDB 1yzq.png
PDB rendering based on 1yzq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAB6A ; RAB6
External IDs OMIM179513 MGI894313 HomoloGene55697 GeneCards: RAB6A Gene
RNA expression pattern
PBB GE RAB6A 210406 s at tn.png
PBB GE RAB6A 201045 s at tn.png
PBB GE RAB6A 201047 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5870 19346
Ensembl ENSG00000175582 ENSMUSG00000030704
UniProt P20340 P35279
RefSeq (mRNA) NM_001243718 NM_001163663
RefSeq (protein) NP_001230647 NP_001157135
Location (UCSC) Chr 11:
73.39 – 73.47 Mb
Chr 7:
100.61 – 100.64 Mb
PubMed search [1] [2]

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.[1] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.


RAB6A has been shown to interact with:


  1. ^ "Entrez Gene: RAB6A RAB6A, member RAS oncogene family". 
  2. ^ a b Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177. 
  3. ^ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. 
  4. ^ Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. 
  5. ^ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science 279 (5350): 580–5. doi:10.1126/science.279.5350.580. PMID 9438855. 
  6. ^ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909. 

Further reading[edit]