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RAB8A, member RAS oncogene family
Protein RAB8A PDB 2fu5.png
PDB rendering based on 2fu5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAB8A ; MEL; RAB8
External IDs OMIM165040 MGI96960 HomoloGene100934 GeneCards: RAB8A Gene
RNA expression pattern
PBB GE RAB8A 208819 at tn.png
More reference expression data
Species Human Mouse
Entrez 4218 17274
Ensembl ENSG00000167461 ENSMUSG00000003037
UniProt P61006 P55258
RefSeq (mRNA) NM_005370 NM_023126
RefSeq (protein) NP_005361 NP_075615
Location (UCSC) Chr 19:
16.22 – 16.25 Mb
Chr 8:
72.16 – 72.18 Mb
PubMed search [1] [2]

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[1][2][3]

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[3]


RAB8A has been shown to interact with Optineurin[4] and MAP4K2.[5]


  1. ^ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (October 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene 6 (8): 1347–51. PMID 1886711. 
  2. ^ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (November 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". J Cell Biol 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815. PMID 8408203. 
  3. ^ a b "Entrez Gene: RAB8A RAB8A, member RAS oncogene family". 
  4. ^ Hattula, K; Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Curr. Biol. (England) 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. ISSN 0960-9822. PMID 11137014. 
  5. ^ Ren, M; Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini D D (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. ISSN 0027-8424. PMC 39423. PMID 8643544. 

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