RAB8A

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RAB8A, member RAS oncogene family
Protein RAB8A PDB 2fu5.png
PDB rendering based on 2fu5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAB8A ; MEL; RAB8
External IDs OMIM165040 MGI96960 HomoloGene100934 GeneCards: RAB8A Gene
RNA expression pattern
PBB GE RAB8A 208819 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4218 17274
Ensembl ENSG00000167461 ENSMUSG00000003037
UniProt P61006 P55258
RefSeq (mRNA) NM_005370 NM_023126
RefSeq (protein) NP_005361 NP_075615
Location (UCSC) Chr 19:
16.22 – 16.25 Mb
Chr 8:
72.16 – 72.18 Mb
PubMed search [1] [2]

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[1][2][3]

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[3]

Interactions[edit]

RAB8A has been shown to interact with Optineurin[4] and MAP4K2.[5]

References[edit]

  1. ^ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (October 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene 6 (8): 1347–51. PMID 1886711. 
  2. ^ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (November 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". J Cell Biol 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815. PMID 8408203. 
  3. ^ a b "Entrez Gene: RAB8A RAB8A, member RAS oncogene family". 
  4. ^ Hattula, K; Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Curr. Biol. (England) 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. ISSN 0960-9822. PMID 11137014. 
  5. ^ Ren, M; Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini D D (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. ISSN 0027-8424. PMC 39423. PMID 8643544. 

Further reading[edit]