RABEP1

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Rabaptin, RAB GTPase binding effector protein 1
Protein RABEP1 PDB 1tu3.png
PDB rendering based on 1tu3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RABEP1 ; RAB5EP; RABPT5
External IDs OMIM603616 MGI1860236 HomoloGene3451 GeneCards: RABEP1 Gene
RNA expression pattern
PBB GE RABEP1 214552 s at tn.png
PBB GE RABEP1 203223 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9135 54189
Ensembl ENSG00000029725 ENSMUSG00000020817
UniProt Q15276 O35551
RefSeq (mRNA) NM_001083585 NM_001291141
RefSeq (protein) NP_001077054 NP_001278070
Location (UCSC) Chr 17:
5.19 – 5.29 Mb
Chr 11:
70.84 – 70.94 Mb
PubMed search [1] [2]

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene.[1][2] It belongs to rabaptin protein family.


Interactions[edit]

RABEP1 has been shown to interact with GGA2,[3] RAB4A,[4] RAB5A,[1][4][5][6] AP1G1[3][7] and GGA1.[3]

References[edit]

  1. ^ a b Stenmark H, Vitale G, Ullrich O, Zerial M (January 1996). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell 83 (3): 423–32. doi:10.1016/0092-8674(95)90120-5. PMID 8521472. 
  2. ^ "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1". 
  3. ^ a b c Mattera, Rafael; Arighi Cecilia N; Lodge Robert; Zerial Marino; Bonifacino Juan S (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5–Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986. 
  4. ^ a b Vitale, G; Rybin V; Christoforidis S; Thornqvist P; McCaffrey M; Stenmark H; Zerial M (April 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". EMBO J. (ENGLAND) 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. ISSN 0261-4189. PMC 1170540. PMID 9524117. 
  5. ^ Xiao, G H; Shoarinejad F; Jin F; Golemis E A; Yeung R S (March 1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". J. Biol. Chem. (UNITED STATES) 272 (10): 6097–100. doi:10.1074/jbc.272.10.6097. ISSN 0021-9258. PMID 9045618. 
  6. ^ Valsdottir, R; Hashimoto H; Ashman K; Koda T; Storrie B; Nilsson T (November 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Lett. (Netherlands) 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. ISSN 0014-5793. PMID 11718716. 
  7. ^ Nogi, Terukazu; Shiba Yoko, Kawasaki Masato, Shiba Tomoo, Matsugaki Naohiro, Igarashi Noriyuki, Suzuki Mamoru, Kato Ryuichi, Takatsu Hiroyuki, Nakayama Kazuhisa, Wakatsuki Soichi (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. (United States) 9 (7): 527–31. doi:10.1038/nsb808. ISSN 1072-8368. PMID 12042876. 

Further reading[edit]