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Rab9 effector protein with kelch motifs
Symbols RABEPK ; RAB9P40; bA65N13.1; p40
External IDs OMIM605962 MGI2139530 HomoloGene48772 GeneCards: RABEPK Gene
RNA expression pattern
PBB GE RABEPK 203150 at tn.png
More reference expression data
Species Human Mouse
Entrez 10244 227746
Ensembl ENSG00000136933 ENSMUSG00000070953
UniProt Q7Z6M1 Q8VCH5
RefSeq (mRNA) NM_001174152 NM_145522
RefSeq (protein) NP_001167623 NP_663497
Location (UCSC) Chr 9:
127.96 – 128 Mb
Chr 2:
34.78 – 34.8 Mb
PubMed search [1] [2]

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.[1][2]

Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.[1]


RABEPK has been shown to interact with RAB9A[1] and FYVE finger-containing phosphoinositide kinase.[3]


  1. ^ a b c Diaz E, Schimmoller F, Pfeffer SR (Aug 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J Cell Biol 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071. 
  2. ^ "Entrez Gene: RABEPK Rab9 effector protein with kelch motifs". 
  3. ^ Ikonomov, Ognian C; Sbrissa Diego; Mlak Krzysztof; Deeb Robert; Fligger Jason; Soans Aleric; Finley Russell L; Shisheva Assia (Dec 2003). "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40". J. Biol. Chem. (United States) 278 (51): 50863–71. doi:10.1074/jbc.M307260200. ISSN 0021-9258. PMID 14530284. 

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