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Rac GTPase activating protein 1
Protein RACGAP1 PDB 2ovj.png
PDB rendering based on 2ovj.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RACGAP1 ; CYK4; HsCYK-4; ID-GAP; MgcRacGAP
External IDs OMIM604980 MGI1349423 HomoloGene8077 GeneCards: RACGAP1 Gene
Species Human Mouse
Entrez 29127 26934
Ensembl ENSG00000161800 ENSMUSG00000023015
UniProt Q9H0H5 Q9WVM1
RefSeq (mRNA) NM_001126103 NM_001253808
RefSeq (protein) NP_001119575 NP_001240737
Location (UCSC) Chr 12:
50.37 – 50.43 Mb
Chr 15:
99.62 – 99.65 Mb
PubMed search [1] [2]

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.[1]

Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM][2]


RACGAP1 has been shown to interact with Rnd2[3] and SLC26A8.[4]

During cytokinesis, RACGAP1 has been shown to interact with KIF23 to form the centralspindlin complex.[5]


  1. ^ Toure A, Dorseuil O, Morin L, Timmons P, Jegou B, Reibel L, Gacon G (April 1998). "MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells". J Biol Chem 273 (11): 6019–23. doi:10.1074/jbc.273.11.6019. PMID 9497316. 
  2. ^ "Entrez Gene: RACGAP1 Rac GTPase activating protein 1". 
  3. ^ Naud, Nathalie; Touré Aminata; Liu Jianfeng; Pineau Charles; Morin Laurence; Dorseuil Olivier; Escalier Denise; Chardin Pierre; Gacon Gérard (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. (England) 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. ISSN 0264-6021. PMC 1223378. PMID 12590651. 
  4. ^ Toure, A; Morin L; Pineau C; Becq F; Dorseuil O; Gacon G (June 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. (United States) 276 (23): 20309–15. doi:10.1074/jbc.M011740200. ISSN 0021-9258. PMID 11278976. 
  5. ^ Glotzer, Michael. "Cytokinesis: Centralspindlin Moonlights as a Membrane Anchor", Current Biology, 18 February 2013

Further reading[edit]