RAD23A

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RAD23 homolog A (S. cerevisiae)
Protein RAD23A PDB 1dv0.png
PDB rendering based on 1dv0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAD23A ; HHR23A; HR23A
External IDs OMIM600061 MGI105126 HomoloGene48322 GeneCards: RAD23A Gene
RNA expression pattern
PBB GE RAD23A 201039 s at tn.png
PBB GE RAD23A 201046 s at tn.png
PBB GE RAD23A 212889 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5886 19358
Ensembl ENSG00000179262 ENSMUSG00000003813
UniProt P54725 P54726
RefSeq (mRNA) NM_001270362 NM_001297606
RefSeq (protein) NP_001257291 NP_001284535
Location (UCSC) Chr 19:
13.06 – 13.06 Mb
Chr 8:
84.83 – 84.84 Mb
PubMed search [1] [2]

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.[1]

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.[2]

Interactions[edit]

RAD23A has been shown to interact with PSMD4,[3][4] Sequestosome 1[5] and Ataxin 3.[6]

References[edit]

  1. ^ van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics 23 (3): 651–658. doi:10.1006/geno.1994.1554. PMID 7851894. 
  2. ^ "Entrez Gene: RAD23A RAD23 homolog A (S. cerevisiae)". 
  3. ^ Hiyama, H; Yokoi M; Masutani C; Sugasawa K; Maekawa T; Tanaka K; Hoeijmakers J H; Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. (UNITED STATES) 274 (39): 28019–28025. doi:10.1074/jbc.274.39.28019. ISSN 0021-9258. PMID 10488153. 
  4. ^ Mueller, Thomas D; Feigon Juli (September 2003). "Structural determinants for the binding of ubiquitin-like domains to the proteasome". EMBO J. (England) 22 (18): 4634–4645. doi:10.1093/emboj/cdg467. ISSN 0261-4189. PMC 212733. PMID 12970176. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Wang, G; Sawai N; Kotliarova S; Kanazawa I; Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. (ENGLAND) 9 (12): 1795–1803. doi:10.1093/hmg/9.12.1795. ISSN 0964-6906. PMID 10915768. 

Further reading[edit]