RAD23B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RAD23 homolog B (S. cerevisiae)
Protein RAD23B PDB 1dv0.png
PDB rendering based on 1dv0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAD23B ; HHR23B; HR23B; P58
External IDs OMIM600062 MGI105128 HomoloGene37704 GeneCards: RAD23B Gene
RNA expression pattern
PBB GE RAD23B 201222 s at tn.png
PBB GE RAD23B 201223 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5887 19359
Ensembl ENSG00000119318 ENSMUSG00000028426
UniProt P54727 P54728
RefSeq (mRNA) NM_001244713 NM_009011
RefSeq (protein) NP_001231642 NP_033037
Location (UCSC) Chr 9:
110.05 – 110.09 Mb
Chr 4:
55.35 – 55.39 Mb
PubMed search [1] [2]

UV excision repair protein RAD23 homolog B is a protein that in humans is encoded by the RAD23B gene.[1][2]

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.[3]

Interactions[edit]

RAD23B has been shown to interact with PSMD4[4] and Ataxin 3.[5]

References[edit]

  1. ^ van der Spek PJ, Smit EM, Beverloo HB, Sugasawa K, Masutani C, Hanaoka F, Hoeijmakers JH, Hagemeijer A (March 1995). "Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23". Genomics 23 (3): 651–8. doi:10.1006/geno.1994.1554. PMID 7851894. 
  2. ^ Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, Takio K, Tanaka K, van der Spek PJ, Bootsma D, et al. (June 1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23". EMBO J 13 (8): 1831–43. PMC 395023. PMID 8168482. 
  3. ^ "Entrez Gene: RAD23B RAD23 homolog B (S. cerevisiae)". 
  4. ^ Hiyama, H; Yokoi M; Masutani C; Sugasawa K; Maekawa T; Tanaka K; Hoeijmakers J H; Hanaoka F (September 1999). "Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome". J. Biol. Chem. (UNITED STATES) 274 (39): 28019–25. doi:10.1074/jbc.274.39.28019. ISSN 0021-9258. PMID 10488153. 
  5. ^ Wang, G; Sawai N; Kotliarova S; Kanazawa I; Nukina N (July 2000). "Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B". Hum. Mol. Genet. (ENGLAND) 9 (12): 1795–803. doi:10.1093/hmg/9.12.1795. ISSN 0964-6906. PMID 10915768. 

Further reading[edit]