RAD51C

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RAD51 paralog C
Identifiers
Symbols RAD51C ; BROVCA3; FANCO; R51H3; RAD51L2
External IDs OMIM602774 MGI2150020 HomoloGene14238 GeneCards: RAD51C Gene
RNA expression pattern
PBB GE RAD51C 206066 s at tn.png
PBB GE RAD51C 209849 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5889 114714
Ensembl ENSG00000108384 ENSMUSG00000007646
UniProt O43502 Q924H5
RefSeq (mRNA) NM_002876 NM_001291440
RefSeq (protein) NP_002867 NP_001278369
Location (UCSC) Chr 17:
56.77 – 56.81 Mb
Chr 11:
87.38 – 87.4 Mb
PubMed search [1] [2]

RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a protein which in humans is encoded by the RAD51C gene.[1][2]

Function[edit]

This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.[1]

Clinical significance[edit]

A characteristic of many cancer cells is that parts of some genes contained within these cells have been recombined with other genes. One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 genes.[3][4] Since the RAD51C protein is involved in repairing double strand chromosome breaks, this chromosomal rearrangement could be responsible for the other rearrangements.[4]

Interactions[edit]

RAD51C has been shown to interact with XRCC3,[5][6][7][8] XRCC2,[6][7] RAD51L3[6][7] and RAD51L1.[5][6][9]

References[edit]

  1. ^ a b "Entrez Gene: RAD51C RAD51 homolog C (S. cerevisiae)". 
  2. ^ Dosanjh MK, Collins DW, Fan W, Lennon GG, Albala JS, Shen Z, Schild D (March 1998). "Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes". Nucleic Acids Res. 26 (5): 1179–84. doi:10.1093/nar/26.5.1179. PMC 147393. PMID 9469824. 
  3. ^ Wade N (2008-12-25). "The Chaos Inside a Cancer Cell". Science Visuals. NYTimes.com. Retrieved 2008-12-29. 
  4. ^ a b Hampton OA, Den Hollander P, Miller CA, Delgado DA, Li J, Coarfa C, Harris RA, Richards S, Scherer SE, Muzny DM, Gibbs RA, Lee AV, Milosavljevic A (December 2008). "A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome". Genome Res. 19 (2): 167–77. doi:10.1101/gr.080259.108. PMC 2652200. PMID 19056696. 
  5. ^ a b Hussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–8. doi:10.1093/hmg/ddh135. ISSN 0964-6906. PMID 15115758. 
  6. ^ a b c d Miller, Kristi A; Yoshikawa Daniel M; McConnell Ian R; Clark Robin; Schild David; Albala Joanna S (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–11. doi:10.1074/jbc.M108306200. ISSN 0021-9258. PMID 11744692. 
  7. ^ a b c Liu, Nan; Schild David; Thelen Michael P; Thompson Larry H (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. (England) 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113. 
  8. ^ Kurumizaka, H; Ikawa S; Nakada M; Eda K; Kagawa W; Takata M; Takeda S; Yokoyama S; Shibata T (May 2001). "Homologous-pairing activity of the human DNA-repair proteins Xrcc3⋅Rad51C". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (10): 5538–43. doi:10.1073/pnas.091603098. ISSN 0027-8424. PMC 33248. PMID 11331762. 
  9. ^ Sigurdsson, S; Van Komen S; Bussen W; Schild D; Albala J S; Sung P (Dec 2001). "Mediator function of the human Rad51B–Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. (United States) 15 (24): 3308–18. doi:10.1101/gad.935501. ISSN 0890-9369. PMC 312844. PMID 11751636. 

Further reading[edit]