This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.
A characteristic of many cancer cells is that parts of some genes contained within these cells have been recombined with other genes. One such gene fusion that has been identified in a MCF-7 breast cancer cell line is a chimera between the RAD51C and ATXN7 genes. Since the RAD51C protein is involved in repairing double strand chromosome breaks, this chromosomal rearrangement could be responsible for the other rearrangements.
^ abHussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–8. doi:10.1093/hmg/ddh135. ISSN0964-6906. PMID15115758.Cite uses deprecated parameters (help)
^ abcdMiller, Kristi A; Yoshikawa Daniel M, McConnell Ian R, Clark Robin, Schild David, Albala Joanna S (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–11. doi:10.1074/jbc.M108306200. ISSN0021-9258. PMID11744692.Cite uses deprecated parameters (help)
Leasure CS, Chandler J, Gilbert DJ, et al. (2001). "Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C". Gene271 (1): 59–67. doi:10.1016/S0378-1119(01)00498-X. PMID11410366.
Miller KA, Yoshikawa DM, McConnell IR, et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem.277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID11744692.
Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ (2003). "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro". J. Biol. Chem.278 (4): 2469–78. doi:10.1074/jbc.M211038200. PMID12427746.
French CA, Tambini CE, Thacker J (2003). "Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion". J. Biol. Chem.278 (46): 45445–50. doi:10.1074/jbc.M308621200. PMID12966089.
Braybrooke JP, Li JL, Wu L, et al. (2004). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem.278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID12975363.