RANK

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Tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TNFRSF11A ; CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
External IDs OMIM603499 MGI1314891 HomoloGene2848 GeneCards: TNFRSF11A Gene
RNA expression pattern
PBB GE TNFRSF11A 207037 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8792 21934
Ensembl ENSG00000141655 ENSMUSG00000026321
UniProt <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en"><head><title>Jobs</title><meta content="text/html; charset=UTF-8" http-equiv="Content-Type"/><link href="/" rel="home"/><link href="http://creativecommons.org/licenses/by-nd/3.0/" rel="license"/><link type="image/vnd.microsoft.icon" href="/favicon.ico" rel="shortcut icon"/><link href="/css-compr.css2013_11" type="text/css" rel="stylesheet"/> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en"><head><title>Jobs</title><meta content="text/html; charset=UTF-8" http-equiv="Content-Type"/><link href="/" rel="home"/><link href="http://creativecommons.org/licenses/by-nd/3.0/" rel="license"/><link type="image/vnd.microsoft.icon" href="/favicon.ico" rel="shortcut icon"/><link href="/css-compr.css2013_11" type="text/css" rel="stylesheet"/> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en"><head><title>Jobs</title><meta content="text/html; charset=UTF-8" http-equiv="Content-Type"/><link href="/" rel="home"/><link href="http://creativecommons.org/licenses/by-nd/3.0/" rel="license"/><link type="image/vnd.microsoft.icon" href="/favicon.ico" rel="shortcut icon"/><link href="/css-compr.css2013_11" type="text/css" rel="stylesheet"/> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en"><head><title>Jobs</title><meta content="text/html; charset=UTF-8" http-equiv="Content-Type"/><link href="/" rel="home"/><link href="http://creativecommons.org/licenses/by-nd/3.0/" rel="license"/><link type="image/vnd.microsoft.icon" href="/favicon.ico" rel="shortcut icon"/><link href="/css-compr.css2013_11" type="text/css" rel="stylesheet"/>
RefSeq (mRNA) NM_001270949 NM_009399
RefSeq (protein) NP_001257878 NP_033425
Location (UCSC) Chr 18:
59.99 – 60.06 Mb
Chr 1:
105.78 – 105.85 Mb
PubMed search [1] [2]

Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.

RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. [1] [2] [3]

Interactions[edit]

RANK has been shown to interact with TRAF6,[4][5][6][7][8] TRAF5,[5][6][7] TRAF1,[7][8] TRAF2[5][6][7][8] and TRAF3.[7][8]

See also[edit]

References[edit]

  1. ^ Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families". Endocr. Rev. 20 (3): 345–57. doi:10.1210/er.20.3.345. PMID 10368775. 
  2. ^ Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function". J. Leukoc. Biol. 65 (6): 715–24. PMID 10380891. 
  3. ^ Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795–823. doi:10.1146/annurev.immunol.20.100301.064753. PMID 11861618. 
  4. ^ Mizukami, Junko; Takaesu Giichi, Akatsuka Hiroyuki, Sakurai Hiroaki, Ninomiya-Tsuji Jun, Matsumoto Kunihiro, Sakurai Naoki (Feb 2002). "Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6". Mol. Cell. Biol. (United States) 22 (4): 992–1000. doi:10.1128/MCB.22.4.992-1000.2002. ISSN 0270-7306. PMC 134634. PMID 11809792. 
  5. ^ a b c Darnay, B G; Haridas V, Ni J, Moore P A, Aggarwal B B (Aug 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412. 
  6. ^ a b c Darnay, B G; Ni J, Moore P A, Aggarwal B B (Mar 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662. 
  7. ^ a b c d e Galibert, L; Tometsko M E, Anderson D M, Cosman D, Dougall W C (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070. 
  8. ^ a b c d Kim, H H; Lee D E, Shin J N, Lee Y S, Jeon Y M, Chung C H, Ni J, Kwon B S, Lee Z H (Jan 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.