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RAP2A, member of RAS oncogene family
Protein RAP2A PDB 1kao.png
PDB rendering based on 1kao.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAP2A ; K-REV; KREV; RAP2; RbBP-30
External IDs OMIM179540 MGI97855 HomoloGene10875 GeneCards: RAP2A Gene
RNA expression pattern
PBB GE RAP2A 214487 s at tn.png
PBB GE RAP2A 221830 at tn.png
More reference expression data
Species Human Mouse
Entrez 5911 76108
Ensembl ENSG00000125249 ENSMUSG00000051615
UniProt P10114 Q80ZJ1
RefSeq (mRNA) NM_021033 NM_029519
RefSeq (protein) NP_066361 NP_083795
Location (UCSC) Chr 13:
98.09 – 98.12 Mb
Chr 14:
120.48 – 120.51 Mb
PubMed search [1] [2]

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.[1] RAP2A is a member of the Ras-related protein family.


RAP2A has been shown to interact with RUNDC3A,[2] RASSF5[3] and RALGDS.[4]


  1. ^ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family". 
  2. ^ Janoueix-Lerosey, I; Pasheva E; de Tand M F; Tavitian A; de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". Eur. J. Biochem. (GERMANY) 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. ISSN 0014-2956. PMID 9523700. 
  3. ^ Ortiz-Vega, Sara; Khokhlatchev Andrei; Nedwidek Maria; Zhang Xian-feng; Dammann Reinhard; Pfeifer Gerd P; Avruch Joseph (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 
  4. ^ Nancy, V; Wolthuis R M, de Tand M F, Janoueix-Lerosey I, Bos J L, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. (UNITED STATES) 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. ISSN 0021-9258. PMID 10085114. 

Further reading[edit]