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RAP2B, member of RAS oncogene family
PBB Protein RAP2A image.jpg
PDB rendering based on 1kao.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAP2B ; MGC20484
External IDs OMIM179541 MGI1921262 HomoloGene55701 GeneCards: RAP2B Gene
RNA expression pattern
PBB GE RAP2B 213923 at tn.png
PBB GE RAP2A 214487 s at tn.png
PBB GE RAP2B 214488 at tn.png
More reference expression data
Species Human Mouse
Entrez 5912 74012
Ensembl ENSG00000181467 ENSMUSG00000036894
UniProt P61225 P61226
RefSeq (mRNA) NM_002886 NM_028712
RefSeq (protein) NP_002877 NP_082988
Location (UCSC) Chr 3:
152.88 – 152.89 Mb
Chr 3:
61.36 – 61.37 Mb
PubMed search [1] [2]

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.[1][2] RAP2B belongs to the Ras-related protein family.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.[2]


  1. ^ Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG (Oct 1990). "RAP2B: a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A 87 (17): 6527–31. doi:10.1073/pnas.87.17.6527. PMC 54569. PMID 2118648. 
  2. ^ a b "Entrez Gene: RAP2B RAP2B, member of RAS oncogene family". 

Further reading[edit]