Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.
^Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID9205841.
^ abcRebhun JF, Castro AF, Quilliam LA (November 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J Biol Chem275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID10934204.
^Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D (May 2000). "The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP". Curr. Biol.10 (9): 555–8. doi:10.1016/S0960-9822(00)00473-5. PMID10801446.
^Emery AC, Eiden MV, Mustafa T, Eiden LE (2013). "Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells". Sci Signal6 (281): ra51. doi:10.1126/scisignal.2003993. PMID23800469.
Ohtsuka T, Hata Y, Ide N, et al. (1999). "nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)". Biochem. Biophys. Res. Commun.265 (1): 38–44. doi:10.1006/bbrc.1999.1619. PMID10548487.
Liao Y, Kariya K, Hu CD, et al. (2000). "RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans". J. Biol. Chem.274 (53): 37815–20. doi:10.1074/jbc.274.53.37815. PMID10608844.
de Rooij J, Boenink NM, van Triest M, et al. (2000). "PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2". J. Biol. Chem.274 (53): 38125–30. doi:10.1074/jbc.274.53.38125. PMID10608883.
Chikumi H, Fukuhara S, Gutkind JS (2002). "Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase". J. Biol. Chem.277 (14): 12463–73. doi:10.1074/jbc.M108504200. PMID11799111.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis.8: 171–84. PMID12107413.