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Rap guanine nucleotide exchange factor (GEF) 2
External IDs OMIM609530 MGI2659071 HomoloGene35477 GeneCards: RAPGEF2 Gene
Species Human Mouse
Entrez 9693 76089
Ensembl ENSG00000109756 ENSMUSG00000062232
UniProt Q9Y4G8 Q8CHG7
RefSeq (mRNA) NM_014247 NM_001099624
RefSeq (protein) NP_055062 NP_001093094
Location (UCSC) Chr 4:
160.03 – 160.28 Mb
Chr 3:
79.06 – 79.18 Mb
PubMed search [1] [2]

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.[1][2][3]

RAPGEF2 is a cyclic AMP binding protein.[4][5]


Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.[2]


RAPGEF2 has been shown to interact with RAP1A[2] and RALGDS.[6]


  1. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  2. ^ a b c Rebhun JF, Castro AF, Quilliam LA (November 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J Biol Chem 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204. 
  3. ^ "Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2". 
  4. ^ Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin D (May 2000). "The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP". Curr. Biol. 10 (9): 555–8. doi:10.1016/S0960-9822(00)00473-5. PMID 10801446. 
  5. ^ Emery AC, Eiden MV, Mustafa T, Eiden LE (2013). "Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells". Sci Signal 6 (281): ra51. doi:10.1126/scisignal.2003993. PMID 23800469. 
  6. ^ Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086. 

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