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Rap guanine nucleotide exchange factor (GEF) 4
Protein RAPGEF4 PDB 1o7f.png
PDB rendering based on 1o7f.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RAPGEF4 ; 2; CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496
External IDs OMIM606058 MGI1917723 HomoloGene4451 IUPHAR: 1293 GeneCards: RAPGEF4 Gene
RNA expression pattern
PBB GE RAPGEF4 205651 x at tn.png
More reference expression data
Species Human Mouse
Entrez 11069 56508
Ensembl ENSG00000091428 ENSMUSG00000049044
UniProt Q8WZA2 Q9EQZ6
RefSeq (mRNA) NM_001100397 NM_001204165
RefSeq (protein) NP_001093867 NP_001191094
Location (UCSC) Chr 2:
173.6 – 173.92 Mb
Chr 2:
71.98 – 72.26 Mb
PubMed search [1] [2]

Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2), is a protein which in humans is encoded by the RAPGEF4 gene.[1][2][3]


RAPGEF4 has been shown to interact with RIMS2.[4][5]


  1. ^ "Entrez Gene: RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4". 
  2. ^ Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM (December 1998). "A family of cAMP-binding proteins that directly activate Rap1". Science 282 (5397): 2275–9. doi:10.1126/science.282.5397.2275. PMID 9856955. 
  3. ^ de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (July 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494. 
  4. ^ Shibasaki, Tadao; Sunaga Yasuhiro; Fujimoto Kei; Kashima Yasushige; Seino Susumu (February 2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis". J. Biol. Chem. (United States) 279 (9): 7956–61. doi:10.1074/jbc.M309068200. ISSN 0021-9258. PMID 14660679. 
  5. ^ Kashima, Y; Miki T; Shibasaki T; Ozaki N; Miyazaki M; Yano H; Seino S (Dec 2001). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. (United States) 276 (49): 46046–53. doi:10.1074/jbc.M108378200. ISSN 0021-9258. PMID 11598134. 

Further reading[edit]