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RAS p21 protein activator 4
External IDs OMIM607943 MGI1858600 HomoloGene5080 GeneCards: RASA4 Gene
Species Human Mouse
Entrez 10156 54153
Ensembl ENSG00000105808 ENSMUSG00000004952
UniProt O43374 Q6PFQ7
RefSeq (mRNA) NM_001079877 NM_001039103
RefSeq (protein) NP_001073346 NP_001034192
Location (UCSC) Chr 7:
102.22 – 102.26 Mb
Chr 5:
136.08 – 136.11 Mb
PubMed search [1] [2]

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[1][2]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. 
  2. ^ a b "Entrez Gene: RASA4 RAS p21 protein activator 4". 

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