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RAS protein activator like 2
Symbols RASAL2 ; NGAP
External IDs OMIM606136 HomoloGene35217 GeneCards: RASAL2 Gene
RNA expression pattern
PBB GE RASAL2 219026 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9462 226525
Ensembl ENSG00000075391 ENSMUSG00000070565
UniProt Q9UJF2 D3YUS5
RefSeq (mRNA) NM_004841 NM_177644
RefSeq (protein) NP_004832 NP_808312
Location (UCSC) Chr 1:
178.06 – 178.45 Mb
Chr 1:
157.14 – 157.41 Mb
PubMed search [1] [2]

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.[1][2]

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[2]


  1. ^ Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett 441 (1): 127–31. doi:10.1016/S0014-5793(98)01530-0. PMID 9877179. 
  2. ^ a b "Entrez Gene: RASAL2 RAS protein activator like 2". 

Further reading[edit]