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Ras association (RalGDS/AF-6) domain family member 2
External IDs OMIM609492 MGI2442060 HomoloGene22840 GeneCards: RASSF2 Gene
RNA expression pattern
PBB GE RASSF2 203185 at tn.png
More reference expression data
Species Human Mouse
Entrez 9770 215653
Ensembl ENSG00000101265 ENSMUSG00000027339
UniProt P50749 Q8BMS9
RefSeq (mRNA) NM_014737 NM_175445
RefSeq (protein) NP_055552 NP_780654
Location (UCSC) Chr 20:
4.76 – 4.8 Mb
Chr 2:
131.99 – 132.03 Mb
PubMed search [1] [2]

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[1][2][3]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[3]


RASSF2 has been shown to interact with KRAS.[4]


  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  2. ^ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169. 
  3. ^ a b "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2". 
  4. ^ Vos, Michele D; Ellis Chad A, Elam Candice, Ulku Aylin S, Taylor Barbara J, Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. (United States) 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644. 

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