RASSF2

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Ras association (RalGDS/AF-6) domain family member 2
Identifiers
Symbols RASSF2 ; CENP-34; RASFADIN
External IDs OMIM609492 MGI2442060 HomoloGene22840 GeneCards: RASSF2 Gene
RNA expression pattern
PBB GE RASSF2 203185 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9770 215653
Ensembl ENSG00000101265 ENSMUSG00000027339
UniProt P50749 Q8BMS9
RefSeq (mRNA) NM_014737 NM_175445
RefSeq (protein) NP_055552 NP_780654
Location (UCSC) Chr 20:
4.76 – 4.8 Mb
Chr 2:
131.99 – 132.03 Mb
PubMed search [1] [2]

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[1][2][3]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[3]

Interactions[edit]

RASSF2 has been shown to interact with KRAS.[4]

References[edit]

  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  2. ^ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169. 
  3. ^ a b "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2". 
  4. ^ Vos, Michele D; Ellis Chad A, Elam Candice, Ulku Aylin S, Taylor Barbara J, Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. (United States) 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644. 

Further reading[edit]