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Ras association (RalGDS/AF-6) domain family member 5
Protein RASSF5 PDB 2fnf.png
PDB rendering based on 2fnf.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607020 MGI1926375 HomoloGene10296 GeneCards: RASSF5 Gene
Species Human Mouse
Entrez 83593 54354
Ensembl ENSG00000136653 ENSMUSG00000026430
UniProt Q8WWW0 Q5EBH1
RefSeq (mRNA) NM_031437 NM_018750
RefSeq (protein) NP_872604 NP_061220
Location (UCSC) Chr 1:
206.68 – 206.76 Mb
Chr 1:
131.18 – 131.25 Mb
PubMed search [1] [2]

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.[1][2][3]

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.[3]


RASSF5 has been shown to interact with RRAS,[4] RAP2A,[4] MRAS[4] and RASSF1.[4]


  1. ^ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenet Cell Genet 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988. 
  2. ^ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544. 
  3. ^ a b "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5". 
  4. ^ a b c d Ortiz-Vega, Sara; Khokhlatchev Andrei; Nedwidek Maria; Zhang Xian-feng; Dammann Reinhard; Pfeifer Gerd P; Avruch Joseph (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 

Further reading[edit]