RB1CC1

RB1-inducible coiled-coil 1
Identifiers
Symbols	RB1CC1; CC1; FIP200
External IDs	OMIM: 606837 MGI: 1341850 HomoloGene: 7659 GeneCards: RB1CC1 Gene
Gene Ontology Molecular function • protein binding Cellular component • pre-autophagosomal structure • nucleus • cytoplasm • cytosol • ULK1-ATG13-FIP200 complex Biological process • liver development • positive regulation of protein phosphorylation • regulation of transcription, DNA-dependent • autophagy • cell cycle • JNK cascade • heart development • negative regulation of apoptosis • positive regulation of cell size Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9821	12421
Ensembl	ENSG00000023287	ENSMUSG00000025907
UniProt	Q8TDY2	Q6NZG0
RefSeq (mRNA)	NM_001083617.1	NM_009826.4
RefSeq (protein)	NP_001077086.1	NP_033956.2
Location (UCSC)	Chr 8: 53.54 – 53.66 Mb	Chr 1: 6.2 – 6.27 Mb
PubMed search	[1]	[2]

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.

Interactions

RB1CC1 has been shown to interact with PTK2B, ASK1 and PTK2.

Further reading

• Nagase T, Seki N, Ishikawa K et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502. 
• Ueda H, Abbi S, Zheng C, Guan JL (2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". J. Cell Biol. 149 (2): 423–430. doi:10.1083/jcb.149.2.423. PMC 2175150. PMID 10769033. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175150. 
• Chano T, Kontani K, Teramoto K et al. (2002). "Truncating mutations of RB1CC1 in human breast cancer". Nat. Genet. 31 (3): 285–288. doi:10.1038/ng911. PMID 12068296. 
• Chano T, Ikegawa S, Saito-Ohara F et al. (2002). "Isolation, characterization and mapping of the mouse and human RB1CC1 genes". Gene 291 (1–2): 29–34. doi:10.1016/S0378-1119(02)00585-1. PMID 12095676. 
• Chano T, Saeki Y, Serra M et al. (2002). "Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells". Am. J. Pathol. 161 (2): 359–64. doi:10.1016/S0002-9440(10)64190-9. PMC 1850752. PMID 12163359. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850752. 
• Abbi S, Ueda H, Zheng C et al. (2003). "Regulation of focal adhesion kinase by a novel protein inhibitor FIP200". Mol. Biol. Cell 13 (9): 3178–3191. doi:10.1091/mbc.E02-05-0295. PMC 124151. PMID 12221124. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124151. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Kontani K, Chano T, Ozaki Y et al. (2004). "RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells". Int. J. Mol. Med. 12 (5): 767–9. PMID 14533007. 
• Bamba N, Chano T, Taga T et al. (2005). "Expression and regulation of RB1CC1 in developing murine and human tissues". Int. J. Mol. Med. 14 (4): 583–7. PMID 15375585. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Watanabe R, Chano T, Inoue H et al. (2005). "Rb1cc1 is critical for myoblast differentiation through Rb1 regulation". Virchows Arch. 447 (3): 643–648. doi:10.1007/s00428-004-1183-1. PMID 15968549. 
• Gan B, Melkoumian ZK, Wu X et al. (2005). "Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control". J. Cell Biol. 170 (3): 379–389. doi:10.1083/jcb.200411106. PMC 2171462. PMID 16043512. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171462. 
• Melkoumian ZK, Peng X, Gan B et al. (2005). "Mechanism of cell cycle regulation by FIP200 in human breast cancer cells". Cancer Res. 65 (15): 6676–6684. doi:10.1158/0008-5472.CAN-04-4142. PMID 16061648. 
• Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Chano T, Saji M, Inoue H et al. (2006). "Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation". Int. J. Mol. Med. 18 (3): 425–32. PMID 16865226. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Lee YC, Yang VC, Wang TS (2007). "Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells". Toxicology 239 (1–2): 108–115. doi:10.1016/j.tox.2007.06.101. PMID 17707572.