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Retinoblastoma binding protein 8
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM604124 MGI2442995 HomoloGene28546 GeneCards: RBBP8 Gene
RNA expression pattern
PBB GE RBBP8 203344 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5932 225182
Ensembl ENSG00000101773 ENSMUSG00000041238
UniProt Q99708 Q80YR6
RefSeq (mRNA) NM_002894 NM_001081223
RefSeq (protein) NP_002885 NP_001074692
Location (UCSC) Chr 18:
20.38 – 20.61 Mb
Chr 18:
11.63 – 11.74 Mb
PubMed search [1] [2]

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.[1][2][3]

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.[3]


RBBP8 has been shown to interact with LMO4,[4][5] Retinoblastoma-like protein 2,[1][6] Retinoblastoma-like protein 1,[1][7] Ataxia telangiectasia mutated,[8][9] Retinoblastoma protein,[1][10] CTBP1,[11][12] SIAH1[13] and BRCA1.[8][11][14][15][16][17][18]


  1. ^ a b c d Fusco C, Reymond A, Zervos AS (October 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205. 
  2. ^ Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (November 2007). "Human CtIP promotes DNA end resection". Nature 450 (7169): 509–14. doi:10.1038/nature06337. PMC 2409435. PMID 17965729. 
  3. ^ a b "Entrez Gene: RBBP8 retinoblastoma binding protein 8". 
  4. ^ Sum, Eleanor Y M; Peng Benjamin, Yu Xin, Chen Junjie, Byrne Jennifer, Lindeman Geoffrey J, Visvader Jane E (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. (United States) 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867. 
  5. ^ Sutherland, Kate D; Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer (United States) 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972. 
  6. ^ Meloni, A R; Smith E J, Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  8. ^ a b Li, S; Ting N S, Zheng L, Chen P L, Ziv Y, Shiloh Y, Lee E Y, Lee W H (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature (ENGLAND) 406 (6792): 210–5. doi:10.1038/35018134. ISSN 0028-0836. PMID 10910365. 
  9. ^ Kim, S T; Lim D S, Canman C E, Kastan M B (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. (UNITED STATES) 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. ISSN 0021-9258. PMID 10608806. 
  10. ^ Dick, F A; Sailhamer E, Dyson N J (May 2000). "Mutagenesis of the pRB Pocket Reveals that Cell Cycle Arrest Functions Are Separable from Binding to Viral Oncoproteins". Mol. Cell. Biol. (UNITED STATES) 20 (10): 3715–27. doi:10.1128/MCB.20.10.3715-3727.2000. ISSN 0270-7306. PMC 85672. PMID 10779361. 
  11. ^ a b Li, S; Chen P L, Subramanian T, Chinnadurai G, Tomlinson G, Osborne C K, Sharp Z D, Lee W H (April 1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem. (UNITED STATES) 274 (16): 11334–8. doi:10.1074/jbc.274.16.11334. ISSN 0021-9258. PMID 10196224. 
  12. ^ Schaeper, U; Subramanian T, Lim L, Boyd J M, Chinnadurai G (April 1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. (UNITED STATES) 273 (15): 8549–52. doi:10.1074/jbc.273.15.8549. ISSN 0021-9258. PMID 9535825. 
  13. ^ Germani, Antonia; Prabel Audrey, Mourah Samia, Podgorniak Marie-Pierre, Di Carlo Anna, Ehrlich Ricardo, Gisselbrecht Sylvie, Varin-Blank Nadine, Calvo Fabien, Bruzzoni-Giovanelli Heriberto (Dec 2003). "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway". Oncogene (England) 22 (55): 8845–51. doi:10.1038/sj.onc.1206994. ISSN 0950-9232. PMID 14654780. 
  14. ^ Rodriguez, Maria; Yu Xiaochun, Chen Junjie, Songyang Zhou (Dec 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. (United States) 278 (52): 52914–8. doi:10.1074/jbc.C300407200. ISSN 0021-9258. PMID 14578343. 
  15. ^ Wong, A K; Ormonde P A, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian S V, Teng D H, Bartel P L (November 1998). "Characterization of a carboxy-terminal BRCA1 interacting protein". Oncogene (ENGLAND) 17 (18): 2279–85. doi:10.1038/sj.onc.1202150. ISSN 0950-9232. PMID 9811458. 
  16. ^ Wu-Baer, F; Baer R (November 2001). "Effect of DNA damage on a BRCA1 complex". Nature (England) 414 (6859): 36. doi:10.1038/35102118. ISSN 0028-0836. PMID 11689934. 
  17. ^ Yu, X; Wu L C, Bowcock A M, Aronheim A, Baer R (September 1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. (UNITED STATES) 273 (39): 25388–92. doi:10.1074/jbc.273.39.25388. ISSN 0021-9258. PMID 9738006. 
  18. ^ Yu, X; Baer R (June 2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. (UNITED STATES) 275 (24): 18541–9. doi:10.1074/jbc.M909494199. ISSN 0021-9258. PMID 10764811. 

Further reading[edit]