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RNA binding motif protein 39
Protein RBM39 PDB 2cq4.png
PDB rendering based on 2cq4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RBM39 ; CAPER; CAPERalpha; FSAP59; HCC1; RNPC2
External IDs OMIM604739 MGI2157953 HomoloGene136465 GeneCards: RBM39 Gene
RNA expression pattern
PBB GE RBM39 208720 s at tn.png
PBB GE RBM39 207941 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9584 170791
Ensembl ENSG00000131051 ENSMUSG00000027620
UniProt Q14498 Q8VH51
RefSeq (mRNA) NM_001242599 NM_001291114
RefSeq (protein) NP_001229528 NP_001278043
Location (UCSC) Chr 20:
34.29 – 34.33 Mb
Chr 2:
156.15 – 156.18 Mb
PubMed search [1] [2]

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[1][2]

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[2]


RBM39 has been shown to interact with Estrogen receptor alpha,[3] Estrogen receptor beta[3] and C-jun.[3]


  1. ^ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425. PMID 8227358. 
  2. ^ a b "Entrez Gene: RBM39 RNA binding motif protein 39". 
  3. ^ a b c Jung, Dong-Ju; Na Soon-Young; Na Doe Sun; Lee Jae Woon (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. (United States) 277 (2): 1229–34. doi:10.1074/jbc.M110417200. ISSN 0021-9258. PMID 11704680. 

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