RBP1

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Retinol binding protein 1, cellular
Protein RBP1 PDB 1crb.png
PDB rendering based on 1crb.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RBP1 ; CRABP-I; CRBP; CRBP1; CRBPI; RBPC
External IDs OMIM180260 MGI97876 HomoloGene2175 ChEMBL: 2076 GeneCards: RBP1 Gene
RNA expression pattern
PBB GE RBP1 203423 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5947 19659
Ensembl ENSG00000114115 ENSMUSG00000046402
UniProt P09455 Q00915
RefSeq (mRNA) NM_001130992 NM_011254
RefSeq (protein) NP_001124464 NP_035384
Location (UCSC) Chr 3:
139.24 – 139.26 Mb
Chr 9:
98.42 – 98.45 Mb
PubMed search [1] [2]

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.[1][2][3]

Function[edit]

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.[1]

Clinical significance[edit]

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.[4]

References[edit]

  1. ^ a b "Entrez Gene: RBP1 retinol binding protein 1, cellular". 
  2. ^ Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334. 
  3. ^ De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3-4): 226–7. doi:10.1159/000015107. PMID 9858824. 
  4. ^ Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. doi:10.1038/modpathol.3800586. PMID 16575402. 

Further reading[edit]