RBP2

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Retinol binding protein 2, cellular
Protein RBP2 PDB 1b4m.png
PDB rendering based on 1b4m.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RBP2 ; CRABP-II; CRBP2; CRBPII; RBPC2
External IDs OMIM180280 MGI97877 HomoloGene3070 IUPHAR: 2547 ChEMBL: 2078 GeneCards: RBP2 Gene
Orthologs
Species Human Mouse
Entrez 5948 19660
Ensembl ENSG00000114113 ENSMUSG00000032454
UniProt P50120 Q08652
RefSeq (mRNA) NM_004164 NM_009034
RefSeq (protein) NP_004155 NP_033060
Location (UCSC) Chr 3:
139.17 – 139.2 Mb
Chr 9:
98.49 – 98.51 Mb
PubMed search [1] [2]

Retinol-binding protein 2 is a protein that in humans is encoded by the RBP2 gene.[1][2][3]

Function[edit]

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.[3]

References[edit]

  1. ^ Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod 10 (5): 1297–304. PMID 7657783. 
  2. ^ De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet 83 (3–4): 240–1. doi:10.1159/000015191. PMID 10072590. 
  3. ^ a b "Entrez Gene: RBP2 retinol binding protein 2, cellular". 

Further reading[edit]

  • van Eijk HG, Tio TH, Bos G (1975). "Iron in skin biopsies". Archiv für dermatologische Forschung 251 (3): 245–8. PMID 1115525. 
  • Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID 1322170. 
  • Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334. 
  • Colantuoni V, Cortese R, Nilsson M, Lundvall J, Båvik CO, Eriksson U et al. (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID 2992469. 
  • Demmer LA, Birkenmeier EH, Sweetser DA, Levin MS, Zollman S, Sparkes RS et al. (1987). "The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene". J. Biol. Chem. 262 (6): 2458–67. PMID 3029082. 
  • Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M et al. (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. doi:10.1073/pnas.061455898. PMC 31117. PMID 11274389. 
  • Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription". J. Biol. Chem. 276 (30): 28402–12. doi:10.1074/jbc.M100313200. PMID 11358960. 
  • Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E et al. (2002). "Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (6): G1079–87. doi:10.1152/ajpgi.00041.2001 (inactive 2015-01-01). PMID 12016134.