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Recombination signal binding protein for immunoglobulin kappa J region
Protein RBPJ PDB 2f8x.png
PDB rendering based on 2f8x.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM147183 MGI96522 HomoloGene7511 GeneCards: RBPJ Gene
RNA expression pattern
PBB GE RBPJ 211974 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3516 19664
Ensembl ENSG00000168214 ENSMUSG00000039191
UniProt Q06330 P31266
RefSeq (mRNA) NM_005349 NM_001080927
RefSeq (protein) NP_005340 NP_001074396
Location (UCSC) Chr 4:
26.17 – 26.44 Mb
Chr 5:
53.56 – 53.66 Mb
PubMed search [1] [2]

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.[1][2][3]

RBPJ[4] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[5]


RBPJ has been shown to interact with:


  1. ^ Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (October 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481. 
  2. ^ Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (November 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". Jpn J Hum Genet 42 (2): 337–41. doi:10.1007/BF02766956. PMID 9290259. 
  3. ^ "Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region". 
  4. ^ "Human Genome Organization: RBPJ Report". 
  5. ^ Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.". Molecular and Cellular Biology 16 (3): 952–959. PMC 231077. PMID 8622698. 
  6. ^ Nam Y, Weng AP, Aster JC, Blacklow SC (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". J. Biol. Chem. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465. 
  7. ^ Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". J. Biol. Chem. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040. 
  8. ^ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. 104 (1-2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. 
  9. ^ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Mol. Cell. Biol. 21 (18): 6222–32. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665. 
  10. ^ Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". J. Biol. Chem. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963. 
  11. ^ a b Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". J. Virol. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367. 
  12. ^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765. 
  13. ^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Mol. Cell. Biol. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164. 

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External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.