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Reticulocalbin 1, EF-hand calcium binding domain
Symbols RCN1 ; PIG20; RCAL; RCN
External IDs OMIM602735 MGI104559 HomoloGene20637 GeneCards: RCN1 Gene
RNA expression pattern
PBB GE RCN1 201063 at tn.png
More reference expression data
Species Human Mouse
Entrez 5954 19672
Ensembl ENSG00000049449 ENSMUSG00000005973
UniProt Q15293 Q05186
RefSeq (mRNA) NM_002901 NM_009037
RefSeq (protein) NP_002892 NP_033063
Location (UCSC) Chr 11:
31.83 – 32.13 Mb
Chr 2:
105.39 – 105.4 Mb
PubMed search [1] [2]

Reticulocalbin-1 is a protein that in humans is encoded by the RCN1 gene.[1][2][3]

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding.[3]


  1. ^ Kent J, Lee M, Schedl A, Boyle S, Fantes J, Powell M, Rushmere N, Abbott C, van Heyningen V, Bickmore WA (Sep 1997). "The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse". Genomics 42 (2): 260–7. doi:10.1006/geno.1997.4706. PMID 9192846. 
  2. ^ Ozawa M (Mar 1996). "Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs". J Biochem 117 (5): 1113–9. PMID 8586628. 
  3. ^ a b "Entrez Gene: RCN1 reticulocalbin 1, EF-hand calcium binding domain". 

Further reading[edit]