RCS-8

RCS-8
Legal status
Legal status	CA: Schedule II; US: Schedule I;
Identifiers
	IUPAC name 2-(2-methoxyphenyl)-1-[1-(2-cyclohexylethyl)indol-3-yl]ethanone;
CAS Number	1345970-42-4 [SciFinder];
ChemSpider	24751863 ;
CompTox Dashboard (EPA)	DTXSID30158821 ;
Chemical and physical data
Formula	C25H29NO2
Molar mass	375.503 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1ccccc1CC(=O)c2cn(c3c2cccc3)CCC4CCCCC4;
	InChI InChI=1S/C25H29NO2/c1-28-25-14-8-5-11-20(25)17-24(27)22-18-26(23-13-7-6-12-21(22)23)16-15-19-9-3-2-4-10-19/h5-8,11-14,18-19H,2-4,9-10,15-17H2,1H3 ; Key:BSQFBMXCQIKYNI-UHFFFAOYSA-N ;
	(what is this?) (verify)

RCS-8, or 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole, is a synthetic cannabinoid also known as SR-18 or BTM-8 that has been found as an ingredient of "herbal" synthetic cannabis blends. It can be described as an analogue of JWH-250 with the 1-pentyl group replaced by 1-(2-cyclohexylethyl), and can be expected to be less potent than JWH-250 (cf. JWH-007 and its cyclohexylethyl analogue).^[1] Despite not having been reported in the scientific or patent literature as yet, reputed recreational use of RCS-8 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act, aiming to add a number of synthetic drugs into Schedule I.^[2]

References

^ Huffman, J. W.; Dai, D.; Martin, B. R.; Compton, D. R. (1994). "Design, Synthesis and Pharmacology of Cannabimimetic Indoles". Bioorganic & Medicinal Chemistry Letters. 4 (4): 563. doi:10.1016/S0960-894X(01)80155-4.
^ Synthetic Drug Control Act of 2011

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[1] Huffman, J. W.; Dai, D.; Martin, B. R.; Compton, D. R. (1994). "Design, Synthesis and Pharmacology of Cannabimimetic Indoles". Bioorganic & Medicinal Chemistry Letters. 4 (4): 563. doi:10.1016/S0960-894X(01)80155-4.

[2] Synthetic Drug Control Act of 2011

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See also

References