From Wikipedia, the free encyclopedia
Jump to: navigation, search
Retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Symbols RDH12 ; LCA13; LCA3; RP53; SDR7C2
External IDs OMIM608830 MGI1925224 HomoloGene110830 GeneCards: RDH12 Gene
EC number 1.1.1.-
RNA expression pattern
PBB GE RDH12 gnf1h02839 s at tn.png
PBB GE RDH12 gnf1h06304 at tn.png
PBB GE RDH12 gnf1h08075 at tn.png
More reference expression data
Species Human Mouse
Entrez 145226 77974
Ensembl ENSG00000139988 ENSMUSG00000021123
UniProt Q96NR8 Q8BYK4
RefSeq (mRNA) NM_152443 NM_030017
RefSeq (protein) NP_689656 NP_084293
Location (UCSC) Chr 14:
68.17 – 68.2 Mb
Chr 12:
79.21 – 79.22 Mb
PubMed search [1] [2]

Retinol dehydrogenase 12 is an enzyme that in humans is encoded by the RDH12 gene.[1][2][3]

Retinoids are indispensable light-sensitive elements of vision and also serve as essential modulators of cellular differentiation and proliferation in diverse cell types. RDH12 belongs to a family of dual-specificity retinol dehydrogenases that metabolize both all-trans- and cis-retinols (Haeseleer et al., 2002).[supplied by OMIM][3]


  1. ^ Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107. 
  2. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. 
  3. ^ a b "Entrez Gene: RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)". 

Further reading[edit]