This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
^Xu H, Beasley MD, Warren WD, van der Horst GT, McKay MJ (Jun 2005). "Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis". Developmental Cell8 (6): 949–61. doi:10.1016/j.devcel.2005.03.018. PMID15935783.
^ abLee J, Iwai T, Yokota T, Yamashita M (Jul 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID12759374.
Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F (Mar 2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Molecular Cell11 (3): 571–5. doi:10.1016/S1097-2765(03)00108-4. PMID12667442.